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Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center

INTRODUCTION: To evaluate the possible effects of the coronavirus disease 2019 (COVID-19) pandemic on the oncologic results of patients with prostate cancer regarding clinical staging, presence of adverse pathological outcomes, and perioperative complications. MATERIALS AND METHODS: This retrospecti...

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Autores principales: Andrade, Guilherme Miranda, Sesconetto, Lucas, da Silva, Rafael Benjamim Rosa, dos Santos, Gabriela Guimarães Rodrigues, Kayano, Paulo Priante, Baccaglini, Willy, Bezerra, Murilo Borges, Bianco, Bianca, Lemos, Gustavo Caserta, Carneiro, Arie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Urologia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247232/
https://www.ncbi.nlm.nih.gov/pubmed/36826377
http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0393
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author Andrade, Guilherme Miranda
Sesconetto, Lucas
da Silva, Rafael Benjamim Rosa
dos Santos, Gabriela Guimarães Rodrigues
Kayano, Paulo Priante
Baccaglini, Willy
Bezerra, Murilo Borges
Bianco, Bianca
Lemos, Gustavo Caserta
Carneiro, Arie
author_facet Andrade, Guilherme Miranda
Sesconetto, Lucas
da Silva, Rafael Benjamim Rosa
dos Santos, Gabriela Guimarães Rodrigues
Kayano, Paulo Priante
Baccaglini, Willy
Bezerra, Murilo Borges
Bianco, Bianca
Lemos, Gustavo Caserta
Carneiro, Arie
author_sort Andrade, Guilherme Miranda
collection PubMed
description INTRODUCTION: To evaluate the possible effects of the coronavirus disease 2019 (COVID-19) pandemic on the oncologic results of patients with prostate cancer regarding clinical staging, presence of adverse pathological outcomes, and perioperative complications. MATERIALS AND METHODS: This retrospective study included patients who underwent radical prostatectomy. The time between biopsy and surgery, staging tests, final histopathological evaluation after surgery, lymphadenectomy rate, postoperative complications, and prostatic specific antigen (PSA) levels (initial and 30 days after surgery) were analyzed and compared in a group of patients before and during the pandemic period. RESULTS: We included 226 patients: 88 in the pre-pandemic period and 138 during the pandemic period. There was no statistically significant difference in mean age, body mass index, ASA, pathological locally advanced disease, the proportion of patients who underwent lymphadenectomy, and ISUP grade in the biopsy between the groups. Positive surgical margins, prostatic extracapsular extension, and PSA levels at 30 days were also similar between the groups. The mean time between medical consultation and surgery was longer in the pandemic period than in the pre-pandemic (124 vs. 107 days, p<0.001), and the mean time between biopsy and medical consultation (69.5 days vs. 114 days, p<0.001) and between biopsy and surgery (198.5 days vs. 228 days, p=0.013) was shorter during the pandemic. The incidence of severe early and late perioperative complications was similar between the periods. CONCLUSIONS: There was no delay between diagnosis and treatment at our institution during the COVID-19 pandemic period. No worsening of the prostate cancer features was observed.
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spelling pubmed-102472322023-06-08 Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center Andrade, Guilherme Miranda Sesconetto, Lucas da Silva, Rafael Benjamim Rosa dos Santos, Gabriela Guimarães Rodrigues Kayano, Paulo Priante Baccaglini, Willy Bezerra, Murilo Borges Bianco, Bianca Lemos, Gustavo Caserta Carneiro, Arie Int Braz J Urol Original Article INTRODUCTION: To evaluate the possible effects of the coronavirus disease 2019 (COVID-19) pandemic on the oncologic results of patients with prostate cancer regarding clinical staging, presence of adverse pathological outcomes, and perioperative complications. MATERIALS AND METHODS: This retrospective study included patients who underwent radical prostatectomy. The time between biopsy and surgery, staging tests, final histopathological evaluation after surgery, lymphadenectomy rate, postoperative complications, and prostatic specific antigen (PSA) levels (initial and 30 days after surgery) were analyzed and compared in a group of patients before and during the pandemic period. RESULTS: We included 226 patients: 88 in the pre-pandemic period and 138 during the pandemic period. There was no statistically significant difference in mean age, body mass index, ASA, pathological locally advanced disease, the proportion of patients who underwent lymphadenectomy, and ISUP grade in the biopsy between the groups. Positive surgical margins, prostatic extracapsular extension, and PSA levels at 30 days were also similar between the groups. The mean time between medical consultation and surgery was longer in the pandemic period than in the pre-pandemic (124 vs. 107 days, p<0.001), and the mean time between biopsy and medical consultation (69.5 days vs. 114 days, p<0.001) and between biopsy and surgery (198.5 days vs. 228 days, p=0.013) was shorter during the pandemic. The incidence of severe early and late perioperative complications was similar between the periods. CONCLUSIONS: There was no delay between diagnosis and treatment at our institution during the COVID-19 pandemic period. No worsening of the prostate cancer features was observed. Sociedade Brasileira de Urologia 2023-02-05 /pmc/articles/PMC10247232/ /pubmed/36826377 http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0393 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Andrade, Guilherme Miranda
Sesconetto, Lucas
da Silva, Rafael Benjamim Rosa
dos Santos, Gabriela Guimarães Rodrigues
Kayano, Paulo Priante
Baccaglini, Willy
Bezerra, Murilo Borges
Bianco, Bianca
Lemos, Gustavo Caserta
Carneiro, Arie
Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
title Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
title_full Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
title_fullStr Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
title_full_unstemmed Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
title_short Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
title_sort impact of covid-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247232/
https://www.ncbi.nlm.nih.gov/pubmed/36826377
http://dx.doi.org/10.1590/S1677-5538.IBJU.2022.0393
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