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Flash glucose monitoring system in patients with type 1 diabetes in healthcare center in Brazil: real world data from a short-term prospective study

OBJECTIVES: To evaluate the alternate use of flash glucose monitoring (FGM) with self-monitoring blood glucose (SMBG), in patients with type 1 diabetes (T1D). MATERIALS AND METHODS: Two weeks of open FGM (P2), both preceded (P1) and followed by 2 weeks (P3) of SMBG with a blinded FGM system. Mean ab...

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Autores principales: Matheus, Alessandra S. M., Pascoal, Juliana Brazil Fontes, Cabizuca, Carolina Alves, Tannus, Lucianne Righeti Monteiro, Guimarães, Rafael Seno, Mattos, Diogo Menezes Ferrazani, Cobas, Roberta Arnoldi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247245/
https://www.ncbi.nlm.nih.gov/pubmed/36468924
http://dx.doi.org/10.20945/2359-3997000000540
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author Matheus, Alessandra S. M.
Pascoal, Juliana Brazil Fontes
Cabizuca, Carolina Alves
Tannus, Lucianne Righeti Monteiro
Guimarães, Rafael Seno
Mattos, Diogo Menezes Ferrazani
Cobas, Roberta Arnoldi
author_facet Matheus, Alessandra S. M.
Pascoal, Juliana Brazil Fontes
Cabizuca, Carolina Alves
Tannus, Lucianne Righeti Monteiro
Guimarães, Rafael Seno
Mattos, Diogo Menezes Ferrazani
Cobas, Roberta Arnoldi
author_sort Matheus, Alessandra S. M.
collection PubMed
description OBJECTIVES: To evaluate the alternate use of flash glucose monitoring (FGM) with self-monitoring blood glucose (SMBG), in patients with type 1 diabetes (T1D). MATERIALS AND METHODS: Two weeks of open FGM (P2), both preceded (P1) and followed by 2 weeks (P3) of SMBG with a blinded FGM system. Mean absolute relative difference (MARD) was calculated by (|FGMi − SMBGi|) / SMBGi, where it was a paired data sample. RESULTS: In total, 34 patients were evaluated. Time in range (TIR) did not change between P1 and P2. In 12 patients (35.3%), TIR increased from 40% at P1 to 52% at P2 (p = 0.002) and in 22 (64.7%), TIR decreased or did not change. FGM use resulted in decreased % time spent in hypoglycemia (<70 mg/dL) (6.5% vs. 5.0%; p = 0.005), increased % time spent in hyperglycemia (>180 mg/dL) (44.5% to 51%; p = 0.046) with no significant change in % TIR. The proportion of patients who reached sensor-estimated glycated hemoglobin (eA1c) < 7% decreased from 23.5% at P1 to 12.9% at P2, p = 0.028. For the whole sample, the MARD between the two methods was 15.5% (95% CI 14.5-16.6%). For normal glucose range, hyperglycemic levels and hypoglycemic levels MARD were 16.0% (95% CI 15.0-17.0%), 13.3% (95% CI 11.5-15.2%) and 23.4% [95% CI 20.5-26.3%)], respectively. CONCLUSION: FGM after usual SMBG decreased the % time spent in hypoglycemia concomitant with an undesired increase in % time spent in hyperglycemia. Lower accuracy of FGM regarding hypoglycemia levels could result in overcorrection of hypoglycemia.
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spelling pubmed-102472452023-06-08 Flash glucose monitoring system in patients with type 1 diabetes in healthcare center in Brazil: real world data from a short-term prospective study Matheus, Alessandra S. M. Pascoal, Juliana Brazil Fontes Cabizuca, Carolina Alves Tannus, Lucianne Righeti Monteiro Guimarães, Rafael Seno Mattos, Diogo Menezes Ferrazani Cobas, Roberta Arnoldi Arch Endocrinol Metab Original Article OBJECTIVES: To evaluate the alternate use of flash glucose monitoring (FGM) with self-monitoring blood glucose (SMBG), in patients with type 1 diabetes (T1D). MATERIALS AND METHODS: Two weeks of open FGM (P2), both preceded (P1) and followed by 2 weeks (P3) of SMBG with a blinded FGM system. Mean absolute relative difference (MARD) was calculated by (|FGMi − SMBGi|) / SMBGi, where it was a paired data sample. RESULTS: In total, 34 patients were evaluated. Time in range (TIR) did not change between P1 and P2. In 12 patients (35.3%), TIR increased from 40% at P1 to 52% at P2 (p = 0.002) and in 22 (64.7%), TIR decreased or did not change. FGM use resulted in decreased % time spent in hypoglycemia (<70 mg/dL) (6.5% vs. 5.0%; p = 0.005), increased % time spent in hyperglycemia (>180 mg/dL) (44.5% to 51%; p = 0.046) with no significant change in % TIR. The proportion of patients who reached sensor-estimated glycated hemoglobin (eA1c) < 7% decreased from 23.5% at P1 to 12.9% at P2, p = 0.028. For the whole sample, the MARD between the two methods was 15.5% (95% CI 14.5-16.6%). For normal glucose range, hyperglycemic levels and hypoglycemic levels MARD were 16.0% (95% CI 15.0-17.0%), 13.3% (95% CI 11.5-15.2%) and 23.4% [95% CI 20.5-26.3%)], respectively. CONCLUSION: FGM after usual SMBG decreased the % time spent in hypoglycemia concomitant with an undesired increase in % time spent in hyperglycemia. Lower accuracy of FGM regarding hypoglycemia levels could result in overcorrection of hypoglycemia. Sociedade Brasileira de Endocrinologia e Metabologia 2022-12-01 /pmc/articles/PMC10247245/ /pubmed/36468924 http://dx.doi.org/10.20945/2359-3997000000540 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Matheus, Alessandra S. M.
Pascoal, Juliana Brazil Fontes
Cabizuca, Carolina Alves
Tannus, Lucianne Righeti Monteiro
Guimarães, Rafael Seno
Mattos, Diogo Menezes Ferrazani
Cobas, Roberta Arnoldi
Flash glucose monitoring system in patients with type 1 diabetes in healthcare center in Brazil: real world data from a short-term prospective study
title Flash glucose monitoring system in patients with type 1 diabetes in healthcare center in Brazil: real world data from a short-term prospective study
title_full Flash glucose monitoring system in patients with type 1 diabetes in healthcare center in Brazil: real world data from a short-term prospective study
title_fullStr Flash glucose monitoring system in patients with type 1 diabetes in healthcare center in Brazil: real world data from a short-term prospective study
title_full_unstemmed Flash glucose monitoring system in patients with type 1 diabetes in healthcare center in Brazil: real world data from a short-term prospective study
title_short Flash glucose monitoring system in patients with type 1 diabetes in healthcare center in Brazil: real world data from a short-term prospective study
title_sort flash glucose monitoring system in patients with type 1 diabetes in healthcare center in brazil: real world data from a short-term prospective study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247245/
https://www.ncbi.nlm.nih.gov/pubmed/36468924
http://dx.doi.org/10.20945/2359-3997000000540
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