AKT inhibition interferes with the expression of immune checkpoint proteins and increases NK-induced killing of HL60-AML cells

OBJECTIVE: To determine the role of the AKT pathway in the regulating of natural Killer-induced apoptosis of acute myeloid leukemia cells and to characterize the associated molecular mechanisms. METHODS: BALB/c nude mice were injected with HL60 cells to induce a xenogenic model of subcutaneous leuke...

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Detalles Bibliográficos
Autores principales: Gama, Sofia Mônaco, Varela, Vanessa Araújo, Ribeiro, Natalia Mazini, Bizzarro, Bruna, Hernandes, Camila, Aloia, Thiago Pinheiro Arrais, Amano, Mariane Tami, Pereira, Welbert Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247281/
https://www.ncbi.nlm.nih.gov/pubmed/37341216
http://dx.doi.org/10.31744/einstein_journal/2023AO0171

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