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Dengue in Early Pregnancy: A Neglected Problem?

Introduction Dengue is caused by a virus from the Flaviviridae family. Although the literature on this disease is sparse, some studies have shown the effects of dengue in the first trimester of pregnancy. However, the sample size in these studies is limited. Aims and objective The current study aime...

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Autores principales: Sinha, Ruchita, Datta, Mamta R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247336/
https://www.ncbi.nlm.nih.gov/pubmed/37303396
http://dx.doi.org/10.7759/cureus.38740
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author Sinha, Ruchita
Datta, Mamta R
author_facet Sinha, Ruchita
Datta, Mamta R
author_sort Sinha, Ruchita
collection PubMed
description Introduction Dengue is caused by a virus from the Flaviviridae family. Although the literature on this disease is sparse, some studies have shown the effects of dengue in the first trimester of pregnancy. However, the sample size in these studies is limited. Aims and objective The current study aimed to compare foetomaternal outcomes in pregnant patients with dengue in early (< 24 weeks) and late (> 24 weeks) pregnancy and find the prevalence and predictive factors for abortion in pregnant patients with dengue. Material and methods This retrospective study included all pregnant patients (n = 62) admitted to the labour room over a period of six years from April 2016 to February 2022 and who were diagnosed with dengue anytime during pregnancy. Data were collected from their medical records and analysed. Differences between the two groups were assessed by the Chi-square test, Fisher’s exact test, and Mann-Whitney U test. A p value of less than 0.05 was considered significant. Results Out of a total of 62 patients, those with dengue at a gestational age of less than 24 weeks (n = 15) had more incidence of intrauterine growth restriction (55.6 vs 12.9%) (p value = 0.012) and oligohydramnios (66.7 vs 17.9%) (p value = 0.007). The incidence of abortion was 33.3%; among the patients at a gestational age of less than 12 weeks, 71.4% had an abortion. When the patients who had abortions were compared with those who did not, the factors predicting abortion were found to be a history of previous abortion (p value = 0.004), gestational age of less than 12 weeks (p value = 0.003), and decreased platelet count (p value = 0.03). Conclusion  The effect of dengue infection in early pregnancy includes abortion, intrauterine growth restriction, and oligohydramnios, and these patients should be managed in a tertiary care hospital.
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spelling pubmed-102473362023-06-09 Dengue in Early Pregnancy: A Neglected Problem? Sinha, Ruchita Datta, Mamta R Cureus Obstetrics/Gynecology Introduction Dengue is caused by a virus from the Flaviviridae family. Although the literature on this disease is sparse, some studies have shown the effects of dengue in the first trimester of pregnancy. However, the sample size in these studies is limited. Aims and objective The current study aimed to compare foetomaternal outcomes in pregnant patients with dengue in early (< 24 weeks) and late (> 24 weeks) pregnancy and find the prevalence and predictive factors for abortion in pregnant patients with dengue. Material and methods This retrospective study included all pregnant patients (n = 62) admitted to the labour room over a period of six years from April 2016 to February 2022 and who were diagnosed with dengue anytime during pregnancy. Data were collected from their medical records and analysed. Differences between the two groups were assessed by the Chi-square test, Fisher’s exact test, and Mann-Whitney U test. A p value of less than 0.05 was considered significant. Results Out of a total of 62 patients, those with dengue at a gestational age of less than 24 weeks (n = 15) had more incidence of intrauterine growth restriction (55.6 vs 12.9%) (p value = 0.012) and oligohydramnios (66.7 vs 17.9%) (p value = 0.007). The incidence of abortion was 33.3%; among the patients at a gestational age of less than 12 weeks, 71.4% had an abortion. When the patients who had abortions were compared with those who did not, the factors predicting abortion were found to be a history of previous abortion (p value = 0.004), gestational age of less than 12 weeks (p value = 0.003), and decreased platelet count (p value = 0.03). Conclusion  The effect of dengue infection in early pregnancy includes abortion, intrauterine growth restriction, and oligohydramnios, and these patients should be managed in a tertiary care hospital. Cureus 2023-05-08 /pmc/articles/PMC10247336/ /pubmed/37303396 http://dx.doi.org/10.7759/cureus.38740 Text en Copyright © 2023, Sinha et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Sinha, Ruchita
Datta, Mamta R
Dengue in Early Pregnancy: A Neglected Problem?
title Dengue in Early Pregnancy: A Neglected Problem?
title_full Dengue in Early Pregnancy: A Neglected Problem?
title_fullStr Dengue in Early Pregnancy: A Neglected Problem?
title_full_unstemmed Dengue in Early Pregnancy: A Neglected Problem?
title_short Dengue in Early Pregnancy: A Neglected Problem?
title_sort dengue in early pregnancy: a neglected problem?
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247336/
https://www.ncbi.nlm.nih.gov/pubmed/37303396
http://dx.doi.org/10.7759/cureus.38740
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