Deterministic evolution and stringent selection during preneoplasia

The earliest events during human tumour initiation, although poorly characterized, may hold clues to malignancy detection and prevention(1). Here we model occult preneoplasia by biallelic inactivation of TP53, a common early event in gastric cancer, in human gastric organoids. Causal relationships b...

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Detalles Bibliográficos
Autores principales: Karlsson, Kasper, Przybilla, Moritz J., Kotler, Eran, Khan, Aziz, Xu, Hang, Karagyozova, Kremena, Sockell, Alexandra, Wong, Wing H., Liu, Katherine, Mah, Amanda, Lo, Yuan-Hung, Lu, Bingxin, Houlahan, Kathleen E., Ma, Zhicheng, Suarez, Carlos J., Barnes, Chris P., Kuo, Calvin J., Curtis, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247377/
https://www.ncbi.nlm.nih.gov/pubmed/37258665
http://dx.doi.org/10.1038/s41586-023-06102-8

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