Emerging roles of the P2X7 receptor in cancer pain

Cancer pain is the most prevalent symptom experienced by cancer patients. It substantially impacts a patient’s long-term physical and emotional health, making it a pressing issue that must be addressed. Purinergic receptor P2X7 (P2X7R) is a widely distributed and potent non-selective ATP-gated ion c...

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Autores principales: Wu, Ping, Wang, Yin, Liu, Yansong, Liu, Yan, Zhou, Guohua, Wu, Xiaoqi, Wen, Qingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247642/
https://www.ncbi.nlm.nih.gov/pubmed/36400869
http://dx.doi.org/10.1007/s11302-022-09902-1
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author Wu, Ping
Wang, Yin
Liu, Yansong
Liu, Yan
Zhou, Guohua
Wu, Xiaoqi
Wen, Qingping
author_facet Wu, Ping
Wang, Yin
Liu, Yansong
Liu, Yan
Zhou, Guohua
Wu, Xiaoqi
Wen, Qingping
author_sort Wu, Ping
collection PubMed
description Cancer pain is the most prevalent symptom experienced by cancer patients. It substantially impacts a patient’s long-term physical and emotional health, making it a pressing issue that must be addressed. Purinergic receptor P2X7 (P2X7R) is a widely distributed and potent non-selective ATP-gated ion channel that regulates tumor proliferation, chronic pain, and the formation of inflammatory lesions in the central nervous system. P2X7R plays an essential role in cancer pain and complications related to cancer pain including depression and opioid tolerance. This review focuses on the structure and distribution of P2X7R, its role in diverse tissues in cancer pain, and the application of P2X7R antagonists in the treatment of cancer pain to propose new ideas for cancer pain management.
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spelling pubmed-102476422023-06-09 Emerging roles of the P2X7 receptor in cancer pain Wu, Ping Wang, Yin Liu, Yansong Liu, Yan Zhou, Guohua Wu, Xiaoqi Wen, Qingping Purinergic Signal Review Article Cancer pain is the most prevalent symptom experienced by cancer patients. It substantially impacts a patient’s long-term physical and emotional health, making it a pressing issue that must be addressed. Purinergic receptor P2X7 (P2X7R) is a widely distributed and potent non-selective ATP-gated ion channel that regulates tumor proliferation, chronic pain, and the formation of inflammatory lesions in the central nervous system. P2X7R plays an essential role in cancer pain and complications related to cancer pain including depression and opioid tolerance. This review focuses on the structure and distribution of P2X7R, its role in diverse tissues in cancer pain, and the application of P2X7R antagonists in the treatment of cancer pain to propose new ideas for cancer pain management. Springer Netherlands 2022-11-19 2023-06 /pmc/articles/PMC10247642/ /pubmed/36400869 http://dx.doi.org/10.1007/s11302-022-09902-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wu, Ping
Wang, Yin
Liu, Yansong
Liu, Yan
Zhou, Guohua
Wu, Xiaoqi
Wen, Qingping
Emerging roles of the P2X7 receptor in cancer pain
title Emerging roles of the P2X7 receptor in cancer pain
title_full Emerging roles of the P2X7 receptor in cancer pain
title_fullStr Emerging roles of the P2X7 receptor in cancer pain
title_full_unstemmed Emerging roles of the P2X7 receptor in cancer pain
title_short Emerging roles of the P2X7 receptor in cancer pain
title_sort emerging roles of the p2x7 receptor in cancer pain
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247642/
https://www.ncbi.nlm.nih.gov/pubmed/36400869
http://dx.doi.org/10.1007/s11302-022-09902-1
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