Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice

The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined wi...

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Detalles Bibliográficos
Autores principales: Emanuelsson, Eric B., Baselet, Bjorn, Neefs, Mieke, Baatout, Sarah, Proesmans, Brit, Daenen, Lisa, Sundberg, Carl Johan, Rundqvist, Helene, Fernandez-Gonzalo, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247796/
https://www.ncbi.nlm.nih.gov/pubmed/37286567
http://dx.doi.org/10.1038/s41526-023-00289-w
Descripción
Sumario:The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle.

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