Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice

The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined wi...

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Autores principales: Emanuelsson, Eric B., Baselet, Bjorn, Neefs, Mieke, Baatout, Sarah, Proesmans, Brit, Daenen, Lisa, Sundberg, Carl Johan, Rundqvist, Helene, Fernandez-Gonzalo, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247796/
https://www.ncbi.nlm.nih.gov/pubmed/37286567
http://dx.doi.org/10.1038/s41526-023-00289-w
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author Emanuelsson, Eric B.
Baselet, Bjorn
Neefs, Mieke
Baatout, Sarah
Proesmans, Brit
Daenen, Lisa
Sundberg, Carl Johan
Rundqvist, Helene
Fernandez-Gonzalo, Rodrigo
author_facet Emanuelsson, Eric B.
Baselet, Bjorn
Neefs, Mieke
Baatout, Sarah
Proesmans, Brit
Daenen, Lisa
Sundberg, Carl Johan
Rundqvist, Helene
Fernandez-Gonzalo, Rodrigo
author_sort Emanuelsson, Eric B.
collection PubMed
description The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle.
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spelling pubmed-102477962023-06-09 Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice Emanuelsson, Eric B. Baselet, Bjorn Neefs, Mieke Baatout, Sarah Proesmans, Brit Daenen, Lisa Sundberg, Carl Johan Rundqvist, Helene Fernandez-Gonzalo, Rodrigo NPJ Microgravity Brief Communication The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle. Nature Publishing Group UK 2023-06-07 /pmc/articles/PMC10247796/ /pubmed/37286567 http://dx.doi.org/10.1038/s41526-023-00289-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Emanuelsson, Eric B.
Baselet, Bjorn
Neefs, Mieke
Baatout, Sarah
Proesmans, Brit
Daenen, Lisa
Sundberg, Carl Johan
Rundqvist, Helene
Fernandez-Gonzalo, Rodrigo
Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice
title Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice
title_full Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice
title_fullStr Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice
title_full_unstemmed Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice
title_short Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice
title_sort myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247796/
https://www.ncbi.nlm.nih.gov/pubmed/37286567
http://dx.doi.org/10.1038/s41526-023-00289-w
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