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Knocking out alpha-synuclein in melanoma cells downregulates L1CAM and decreases motility

The Parkinson’s disease (PD) associated protein, alpha-synuclein (α-syn/SNCA), is highly expressed in aggressive melanomas. The goal of this study was to reveal possible mechanism(s) of α-syn involvement in melanoma pathogenesis. Herein, we asked whether α-syn modulates the expression of the pro-onc...

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Detalles Bibliográficos
Autores principales:	Gajendran, Nithya, Rajasekaran, Santhanasabapathy, Witt, Stephan N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247798/ https://www.ncbi.nlm.nih.gov/pubmed/37286800 http://dx.doi.org/10.1038/s41598-023-36451-3

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