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Drug self-poisoning in adolescents: A report of 267 cases
INTRODUCTION: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication. METHODS: We retrospectively reviewed the cases of drug sel...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247951/ https://www.ncbi.nlm.nih.gov/pubmed/37304378 http://dx.doi.org/10.1016/j.toxrep.2023.05.012 |
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author | Roversi, Marco Martini, Matteo Musolino, Antonio Pisani, Mara Zampini, Giorgio Genuini, Leonardo Bottari, Gabriella Di Nardo, Matteo Stoppa, Francesca Marano, Marco |
author_facet | Roversi, Marco Martini, Matteo Musolino, Antonio Pisani, Mara Zampini, Giorgio Genuini, Leonardo Bottari, Gabriella Di Nardo, Matteo Stoppa, Francesca Marano, Marco |
author_sort | Roversi, Marco |
collection | PubMed |
description | INTRODUCTION: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication. METHODS: We retrospectively reviewed the cases of drug self-poisoning in adolescents admitted to the Bambino Gesù Children’s Hospital between January 2014 and June 2022 requiring consultation by the local Pediatric Poison Control Center (PPCC). We reported the type and class of drug ingested and correlated the clinical characteristics of the patients with their Poison Severity Score. RESULTS: The data of 267 patients were reported. Most patients were female (85.8 %), with a median age of 15.8 years at presentation. Half of the patients were symptomatic at admission (44.2 %), and most had at least one psychiatric comorbidity (71.1 %). Most patients were hospitalized (79.6 %), 16.6 % of cases required antidote administration and a minority required intensive care. Most patients received a PSS score of 0 (59.6 %). The most frequently ingested drug was acetaminophen (28.1 %) followed by ibuprofen (10.1 %) and aripiprazole (10.1 %). Antipsychotics as a class were the most abused drugs (33.1 %). The correlation of clinical variables with the PSS showed that older and male patients were more prone to be severely intoxicated. CONCLUSIONS: This single-center study identifies the most commonly ingested drugs in a large sample of adolescents with voluntary drug self-poisoning, also showing that older and male patients are more susceptible to severe intoxication. |
format | Online Article Text |
id | pubmed-10247951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102479512023-06-09 Drug self-poisoning in adolescents: A report of 267 cases Roversi, Marco Martini, Matteo Musolino, Antonio Pisani, Mara Zampini, Giorgio Genuini, Leonardo Bottari, Gabriella Di Nardo, Matteo Stoppa, Francesca Marano, Marco Toxicol Rep Article INTRODUCTION: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication. METHODS: We retrospectively reviewed the cases of drug self-poisoning in adolescents admitted to the Bambino Gesù Children’s Hospital between January 2014 and June 2022 requiring consultation by the local Pediatric Poison Control Center (PPCC). We reported the type and class of drug ingested and correlated the clinical characteristics of the patients with their Poison Severity Score. RESULTS: The data of 267 patients were reported. Most patients were female (85.8 %), with a median age of 15.8 years at presentation. Half of the patients were symptomatic at admission (44.2 %), and most had at least one psychiatric comorbidity (71.1 %). Most patients were hospitalized (79.6 %), 16.6 % of cases required antidote administration and a minority required intensive care. Most patients received a PSS score of 0 (59.6 %). The most frequently ingested drug was acetaminophen (28.1 %) followed by ibuprofen (10.1 %) and aripiprazole (10.1 %). Antipsychotics as a class were the most abused drugs (33.1 %). The correlation of clinical variables with the PSS showed that older and male patients were more prone to be severely intoxicated. CONCLUSIONS: This single-center study identifies the most commonly ingested drugs in a large sample of adolescents with voluntary drug self-poisoning, also showing that older and male patients are more susceptible to severe intoxication. Elsevier 2023-05-29 /pmc/articles/PMC10247951/ /pubmed/37304378 http://dx.doi.org/10.1016/j.toxrep.2023.05.012 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Roversi, Marco Martini, Matteo Musolino, Antonio Pisani, Mara Zampini, Giorgio Genuini, Leonardo Bottari, Gabriella Di Nardo, Matteo Stoppa, Francesca Marano, Marco Drug self-poisoning in adolescents: A report of 267 cases |
title | Drug self-poisoning in adolescents: A report of 267 cases |
title_full | Drug self-poisoning in adolescents: A report of 267 cases |
title_fullStr | Drug self-poisoning in adolescents: A report of 267 cases |
title_full_unstemmed | Drug self-poisoning in adolescents: A report of 267 cases |
title_short | Drug self-poisoning in adolescents: A report of 267 cases |
title_sort | drug self-poisoning in adolescents: a report of 267 cases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247951/ https://www.ncbi.nlm.nih.gov/pubmed/37304378 http://dx.doi.org/10.1016/j.toxrep.2023.05.012 |
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