Cargando…

Drug self-poisoning in adolescents: A report of 267 cases

INTRODUCTION: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication. METHODS: We retrospectively reviewed the cases of drug sel...

Descripción completa

Detalles Bibliográficos
Autores principales: Roversi, Marco, Martini, Matteo, Musolino, Antonio, Pisani, Mara, Zampini, Giorgio, Genuini, Leonardo, Bottari, Gabriella, Di Nardo, Matteo, Stoppa, Francesca, Marano, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247951/
https://www.ncbi.nlm.nih.gov/pubmed/37304378
http://dx.doi.org/10.1016/j.toxrep.2023.05.012
_version_ 1785055262467424256
author Roversi, Marco
Martini, Matteo
Musolino, Antonio
Pisani, Mara
Zampini, Giorgio
Genuini, Leonardo
Bottari, Gabriella
Di Nardo, Matteo
Stoppa, Francesca
Marano, Marco
author_facet Roversi, Marco
Martini, Matteo
Musolino, Antonio
Pisani, Mara
Zampini, Giorgio
Genuini, Leonardo
Bottari, Gabriella
Di Nardo, Matteo
Stoppa, Francesca
Marano, Marco
author_sort Roversi, Marco
collection PubMed
description INTRODUCTION: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication. METHODS: We retrospectively reviewed the cases of drug self-poisoning in adolescents admitted to the Bambino Gesù Children’s Hospital between January 2014 and June 2022 requiring consultation by the local Pediatric Poison Control Center (PPCC). We reported the type and class of drug ingested and correlated the clinical characteristics of the patients with their Poison Severity Score. RESULTS: The data of 267 patients were reported. Most patients were female (85.8 %), with a median age of 15.8 years at presentation. Half of the patients were symptomatic at admission (44.2 %), and most had at least one psychiatric comorbidity (71.1 %). Most patients were hospitalized (79.6 %), 16.6 % of cases required antidote administration and a minority required intensive care. Most patients received a PSS score of 0 (59.6 %). The most frequently ingested drug was acetaminophen (28.1 %) followed by ibuprofen (10.1 %) and aripiprazole (10.1 %). Antipsychotics as a class were the most abused drugs (33.1 %). The correlation of clinical variables with the PSS showed that older and male patients were more prone to be severely intoxicated. CONCLUSIONS: This single-center study identifies the most commonly ingested drugs in a large sample of adolescents with voluntary drug self-poisoning, also showing that older and male patients are more susceptible to severe intoxication.
format Online
Article
Text
id pubmed-10247951
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-102479512023-06-09 Drug self-poisoning in adolescents: A report of 267 cases Roversi, Marco Martini, Matteo Musolino, Antonio Pisani, Mara Zampini, Giorgio Genuini, Leonardo Bottari, Gabriella Di Nardo, Matteo Stoppa, Francesca Marano, Marco Toxicol Rep Article INTRODUCTION: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication. METHODS: We retrospectively reviewed the cases of drug self-poisoning in adolescents admitted to the Bambino Gesù Children’s Hospital between January 2014 and June 2022 requiring consultation by the local Pediatric Poison Control Center (PPCC). We reported the type and class of drug ingested and correlated the clinical characteristics of the patients with their Poison Severity Score. RESULTS: The data of 267 patients were reported. Most patients were female (85.8 %), with a median age of 15.8 years at presentation. Half of the patients were symptomatic at admission (44.2 %), and most had at least one psychiatric comorbidity (71.1 %). Most patients were hospitalized (79.6 %), 16.6 % of cases required antidote administration and a minority required intensive care. Most patients received a PSS score of 0 (59.6 %). The most frequently ingested drug was acetaminophen (28.1 %) followed by ibuprofen (10.1 %) and aripiprazole (10.1 %). Antipsychotics as a class were the most abused drugs (33.1 %). The correlation of clinical variables with the PSS showed that older and male patients were more prone to be severely intoxicated. CONCLUSIONS: This single-center study identifies the most commonly ingested drugs in a large sample of adolescents with voluntary drug self-poisoning, also showing that older and male patients are more susceptible to severe intoxication. Elsevier 2023-05-29 /pmc/articles/PMC10247951/ /pubmed/37304378 http://dx.doi.org/10.1016/j.toxrep.2023.05.012 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Roversi, Marco
Martini, Matteo
Musolino, Antonio
Pisani, Mara
Zampini, Giorgio
Genuini, Leonardo
Bottari, Gabriella
Di Nardo, Matteo
Stoppa, Francesca
Marano, Marco
Drug self-poisoning in adolescents: A report of 267 cases
title Drug self-poisoning in adolescents: A report of 267 cases
title_full Drug self-poisoning in adolescents: A report of 267 cases
title_fullStr Drug self-poisoning in adolescents: A report of 267 cases
title_full_unstemmed Drug self-poisoning in adolescents: A report of 267 cases
title_short Drug self-poisoning in adolescents: A report of 267 cases
title_sort drug self-poisoning in adolescents: a report of 267 cases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247951/
https://www.ncbi.nlm.nih.gov/pubmed/37304378
http://dx.doi.org/10.1016/j.toxrep.2023.05.012
work_keys_str_mv AT roversimarco drugselfpoisoninginadolescentsareportof267cases
AT martinimatteo drugselfpoisoninginadolescentsareportof267cases
AT musolinoantonio drugselfpoisoninginadolescentsareportof267cases
AT pisanimara drugselfpoisoninginadolescentsareportof267cases
AT zampinigiorgio drugselfpoisoninginadolescentsareportof267cases
AT genuinileonardo drugselfpoisoninginadolescentsareportof267cases
AT bottarigabriella drugselfpoisoninginadolescentsareportof267cases
AT dinardomatteo drugselfpoisoninginadolescentsareportof267cases
AT stoppafrancesca drugselfpoisoninginadolescentsareportof267cases
AT maranomarco drugselfpoisoninginadolescentsareportof267cases