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Harnessing type I interferon-mediated immunity to target malignant brain tumors

Type I interferons have long been appreciated as a cytokine family that regulates antiviral immunity. Recently, their role in eliciting antitumor immune responses has gained increasing attention. Within the immunosuppressive tumor microenvironment (TME), interferons stimulate tumor-infiltrating lymp...

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Autores principales: Lim, Juhee, Kang, In, La, Jeongwoo, Ku, Keun Bon, Kang, Byeong Hoon, Kim, Yumin, Park, Won Hyung, Lee, Heung Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247981/
https://www.ncbi.nlm.nih.gov/pubmed/37304294
http://dx.doi.org/10.3389/fimmu.2023.1203929
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author Lim, Juhee
Kang, In
La, Jeongwoo
Ku, Keun Bon
Kang, Byeong Hoon
Kim, Yumin
Park, Won Hyung
Lee, Heung Kyu
author_facet Lim, Juhee
Kang, In
La, Jeongwoo
Ku, Keun Bon
Kang, Byeong Hoon
Kim, Yumin
Park, Won Hyung
Lee, Heung Kyu
author_sort Lim, Juhee
collection PubMed
description Type I interferons have long been appreciated as a cytokine family that regulates antiviral immunity. Recently, their role in eliciting antitumor immune responses has gained increasing attention. Within the immunosuppressive tumor microenvironment (TME), interferons stimulate tumor-infiltrating lymphocytes to promote immune clearance and essentially reshape a “cold” TME into an immune-activating “hot” TME. In this review, we focus on gliomas, with an emphasis on malignant glioblastoma, as these brain tumors possess a highly invasive and heterogenous brain TME. We address how type I interferons regulate antitumor immune responses against malignant gliomas and reshape the overall immune landscape of the brain TME. Furthermore, we discuss how these findings can translate into future immunotherapies targeting brain tumors in general.
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spelling pubmed-102479812023-06-09 Harnessing type I interferon-mediated immunity to target malignant brain tumors Lim, Juhee Kang, In La, Jeongwoo Ku, Keun Bon Kang, Byeong Hoon Kim, Yumin Park, Won Hyung Lee, Heung Kyu Front Immunol Immunology Type I interferons have long been appreciated as a cytokine family that regulates antiviral immunity. Recently, their role in eliciting antitumor immune responses has gained increasing attention. Within the immunosuppressive tumor microenvironment (TME), interferons stimulate tumor-infiltrating lymphocytes to promote immune clearance and essentially reshape a “cold” TME into an immune-activating “hot” TME. In this review, we focus on gliomas, with an emphasis on malignant glioblastoma, as these brain tumors possess a highly invasive and heterogenous brain TME. We address how type I interferons regulate antitumor immune responses against malignant gliomas and reshape the overall immune landscape of the brain TME. Furthermore, we discuss how these findings can translate into future immunotherapies targeting brain tumors in general. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10247981/ /pubmed/37304294 http://dx.doi.org/10.3389/fimmu.2023.1203929 Text en Copyright © 2023 Lim, Kang, La, Ku, Kang, Kim, Park and Lee https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lim, Juhee
Kang, In
La, Jeongwoo
Ku, Keun Bon
Kang, Byeong Hoon
Kim, Yumin
Park, Won Hyung
Lee, Heung Kyu
Harnessing type I interferon-mediated immunity to target malignant brain tumors
title Harnessing type I interferon-mediated immunity to target malignant brain tumors
title_full Harnessing type I interferon-mediated immunity to target malignant brain tumors
title_fullStr Harnessing type I interferon-mediated immunity to target malignant brain tumors
title_full_unstemmed Harnessing type I interferon-mediated immunity to target malignant brain tumors
title_short Harnessing type I interferon-mediated immunity to target malignant brain tumors
title_sort harnessing type i interferon-mediated immunity to target malignant brain tumors
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247981/
https://www.ncbi.nlm.nih.gov/pubmed/37304294
http://dx.doi.org/10.3389/fimmu.2023.1203929
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