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Harnessing type I interferon-mediated immunity to target malignant brain tumors
Type I interferons have long been appreciated as a cytokine family that regulates antiviral immunity. Recently, their role in eliciting antitumor immune responses has gained increasing attention. Within the immunosuppressive tumor microenvironment (TME), interferons stimulate tumor-infiltrating lymp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247981/ https://www.ncbi.nlm.nih.gov/pubmed/37304294 http://dx.doi.org/10.3389/fimmu.2023.1203929 |
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author | Lim, Juhee Kang, In La, Jeongwoo Ku, Keun Bon Kang, Byeong Hoon Kim, Yumin Park, Won Hyung Lee, Heung Kyu |
author_facet | Lim, Juhee Kang, In La, Jeongwoo Ku, Keun Bon Kang, Byeong Hoon Kim, Yumin Park, Won Hyung Lee, Heung Kyu |
author_sort | Lim, Juhee |
collection | PubMed |
description | Type I interferons have long been appreciated as a cytokine family that regulates antiviral immunity. Recently, their role in eliciting antitumor immune responses has gained increasing attention. Within the immunosuppressive tumor microenvironment (TME), interferons stimulate tumor-infiltrating lymphocytes to promote immune clearance and essentially reshape a “cold” TME into an immune-activating “hot” TME. In this review, we focus on gliomas, with an emphasis on malignant glioblastoma, as these brain tumors possess a highly invasive and heterogenous brain TME. We address how type I interferons regulate antitumor immune responses against malignant gliomas and reshape the overall immune landscape of the brain TME. Furthermore, we discuss how these findings can translate into future immunotherapies targeting brain tumors in general. |
format | Online Article Text |
id | pubmed-10247981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102479812023-06-09 Harnessing type I interferon-mediated immunity to target malignant brain tumors Lim, Juhee Kang, In La, Jeongwoo Ku, Keun Bon Kang, Byeong Hoon Kim, Yumin Park, Won Hyung Lee, Heung Kyu Front Immunol Immunology Type I interferons have long been appreciated as a cytokine family that regulates antiviral immunity. Recently, their role in eliciting antitumor immune responses has gained increasing attention. Within the immunosuppressive tumor microenvironment (TME), interferons stimulate tumor-infiltrating lymphocytes to promote immune clearance and essentially reshape a “cold” TME into an immune-activating “hot” TME. In this review, we focus on gliomas, with an emphasis on malignant glioblastoma, as these brain tumors possess a highly invasive and heterogenous brain TME. We address how type I interferons regulate antitumor immune responses against malignant gliomas and reshape the overall immune landscape of the brain TME. Furthermore, we discuss how these findings can translate into future immunotherapies targeting brain tumors in general. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10247981/ /pubmed/37304294 http://dx.doi.org/10.3389/fimmu.2023.1203929 Text en Copyright © 2023 Lim, Kang, La, Ku, Kang, Kim, Park and Lee https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lim, Juhee Kang, In La, Jeongwoo Ku, Keun Bon Kang, Byeong Hoon Kim, Yumin Park, Won Hyung Lee, Heung Kyu Harnessing type I interferon-mediated immunity to target malignant brain tumors |
title | Harnessing type I interferon-mediated immunity to target malignant brain tumors |
title_full | Harnessing type I interferon-mediated immunity to target malignant brain tumors |
title_fullStr | Harnessing type I interferon-mediated immunity to target malignant brain tumors |
title_full_unstemmed | Harnessing type I interferon-mediated immunity to target malignant brain tumors |
title_short | Harnessing type I interferon-mediated immunity to target malignant brain tumors |
title_sort | harnessing type i interferon-mediated immunity to target malignant brain tumors |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247981/ https://www.ncbi.nlm.nih.gov/pubmed/37304294 http://dx.doi.org/10.3389/fimmu.2023.1203929 |
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