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SLC26 family: a new insight for kidney stone disease

The solute-linked carrier 26 (SLC26) protein family is comprised of multifunctional transporters of substrates that include oxalate, sulphate, and chloride. Disorders of oxalate homeostasis cause hyperoxalemia and hyperoxaluria, leading to urinary calcium oxalate precipitation and urolithogenesis. S...

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Detalles Bibliográficos
Autores principales: Li, Jialin, Huang, Sigen, Liu, Shengyin, Liao, Xinzhi, Yan, Sheng, Liu, Quanliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247987/
https://www.ncbi.nlm.nih.gov/pubmed/37304821
http://dx.doi.org/10.3389/fphys.2023.1118342
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author Li, Jialin
Huang, Sigen
Liu, Shengyin
Liao, Xinzhi
Yan, Sheng
Liu, Quanliang
author_facet Li, Jialin
Huang, Sigen
Liu, Shengyin
Liao, Xinzhi
Yan, Sheng
Liu, Quanliang
author_sort Li, Jialin
collection PubMed
description The solute-linked carrier 26 (SLC26) protein family is comprised of multifunctional transporters of substrates that include oxalate, sulphate, and chloride. Disorders of oxalate homeostasis cause hyperoxalemia and hyperoxaluria, leading to urinary calcium oxalate precipitation and urolithogenesis. SLC26 proteins are aberrantly expressed during kidney stone formation, and consequently may present therapeutic targets. SLC26 protein inhibitors are in preclinical development. In this review, we integrate the findings of recent reports with clinical data to highlight the role of SLC26 proteins in oxalate metabolism during urolithogenesis, and discuss limitations of current studies and potential directions for future research.
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spelling pubmed-102479872023-06-09 SLC26 family: a new insight for kidney stone disease Li, Jialin Huang, Sigen Liu, Shengyin Liao, Xinzhi Yan, Sheng Liu, Quanliang Front Physiol Physiology The solute-linked carrier 26 (SLC26) protein family is comprised of multifunctional transporters of substrates that include oxalate, sulphate, and chloride. Disorders of oxalate homeostasis cause hyperoxalemia and hyperoxaluria, leading to urinary calcium oxalate precipitation and urolithogenesis. SLC26 proteins are aberrantly expressed during kidney stone formation, and consequently may present therapeutic targets. SLC26 protein inhibitors are in preclinical development. In this review, we integrate the findings of recent reports with clinical data to highlight the role of SLC26 proteins in oxalate metabolism during urolithogenesis, and discuss limitations of current studies and potential directions for future research. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10247987/ /pubmed/37304821 http://dx.doi.org/10.3389/fphys.2023.1118342 Text en Copyright © 2023 Li, Huang, Liu, Liao, Yan and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Li, Jialin
Huang, Sigen
Liu, Shengyin
Liao, Xinzhi
Yan, Sheng
Liu, Quanliang
SLC26 family: a new insight for kidney stone disease
title SLC26 family: a new insight for kidney stone disease
title_full SLC26 family: a new insight for kidney stone disease
title_fullStr SLC26 family: a new insight for kidney stone disease
title_full_unstemmed SLC26 family: a new insight for kidney stone disease
title_short SLC26 family: a new insight for kidney stone disease
title_sort slc26 family: a new insight for kidney stone disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247987/
https://www.ncbi.nlm.nih.gov/pubmed/37304821
http://dx.doi.org/10.3389/fphys.2023.1118342
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