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Full-scale numerical simulation of hemodynamics based on left ventricular assist device
Ventricular assist devices have been widely used and accepted to treat patients with end-stage heart failure. The role of VAD is to improve circulatory dysfunction or temporarily maintain the circulatory status of patients. In order to be closer to the medical practice, a multi-Domain model of the l...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248007/ https://www.ncbi.nlm.nih.gov/pubmed/37304828 http://dx.doi.org/10.3389/fphys.2023.1192610 |
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author | Gao, Xinyi Xu, Zhike Chen, Chenghan Hao, Pengfei He, Feng Zhang, Xiwen |
author_facet | Gao, Xinyi Xu, Zhike Chen, Chenghan Hao, Pengfei He, Feng Zhang, Xiwen |
author_sort | Gao, Xinyi |
collection | PubMed |
description | Ventricular assist devices have been widely used and accepted to treat patients with end-stage heart failure. The role of VAD is to improve circulatory dysfunction or temporarily maintain the circulatory status of patients. In order to be closer to the medical practice, a multi-Domain model of the left ventricular coupled axial flow artificial heart was considered to study the effect of its hemodynamics on the aorta. Because whether LVAD itself was connected between the left ventricular apex and the ascending aorta by catheter in the loop was not very important for the analysis of simulation results, on the premise of ensuring the multi-Domain simulation, the simulation data of the import and export ends of LVAD were imported to simplify the model. In this paper, the hemodynamic parameters in the ascending aorta, such as blood flow velocity vector, wall shear stress distribution, vorticity current intensity, vorticity flow generation, etc., have been calculated. The numerical conclusion of this study showed the vorticity intensity under LVAD was significantly higher than that under patients’ conditions and the overall condition is similar to that of a healthy ventricular spin, which can improve heart failure patients’ condition while minimizing other pitfalls. In addition, high velocity blood flow during left ventricular assist surgery is mainly concentrated near the lining of the ascending aorta lumen. What’s more, the paper proposes to use Q criterion to determine the generation of vorticity flow. The Q criterion of LVAD is much higher than that of patients with heart failure, and the closer the LVAD is to the wall of the ascending aorta, the greater the Q criterion is. All these are beneficial to the effectiveness of LVAD in the treatment of heart failure patients and provide clinical suggestions for the LVAD implantation in clinical practice. |
format | Online Article Text |
id | pubmed-10248007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102480072023-06-09 Full-scale numerical simulation of hemodynamics based on left ventricular assist device Gao, Xinyi Xu, Zhike Chen, Chenghan Hao, Pengfei He, Feng Zhang, Xiwen Front Physiol Physiology Ventricular assist devices have been widely used and accepted to treat patients with end-stage heart failure. The role of VAD is to improve circulatory dysfunction or temporarily maintain the circulatory status of patients. In order to be closer to the medical practice, a multi-Domain model of the left ventricular coupled axial flow artificial heart was considered to study the effect of its hemodynamics on the aorta. Because whether LVAD itself was connected between the left ventricular apex and the ascending aorta by catheter in the loop was not very important for the analysis of simulation results, on the premise of ensuring the multi-Domain simulation, the simulation data of the import and export ends of LVAD were imported to simplify the model. In this paper, the hemodynamic parameters in the ascending aorta, such as blood flow velocity vector, wall shear stress distribution, vorticity current intensity, vorticity flow generation, etc., have been calculated. The numerical conclusion of this study showed the vorticity intensity under LVAD was significantly higher than that under patients’ conditions and the overall condition is similar to that of a healthy ventricular spin, which can improve heart failure patients’ condition while minimizing other pitfalls. In addition, high velocity blood flow during left ventricular assist surgery is mainly concentrated near the lining of the ascending aorta lumen. What’s more, the paper proposes to use Q criterion to determine the generation of vorticity flow. The Q criterion of LVAD is much higher than that of patients with heart failure, and the closer the LVAD is to the wall of the ascending aorta, the greater the Q criterion is. All these are beneficial to the effectiveness of LVAD in the treatment of heart failure patients and provide clinical suggestions for the LVAD implantation in clinical practice. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10248007/ /pubmed/37304828 http://dx.doi.org/10.3389/fphys.2023.1192610 Text en Copyright © 2023 Gao, Xu, Chen, Hao, He and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Gao, Xinyi Xu, Zhike Chen, Chenghan Hao, Pengfei He, Feng Zhang, Xiwen Full-scale numerical simulation of hemodynamics based on left ventricular assist device |
title | Full-scale numerical simulation of hemodynamics based on left ventricular assist device |
title_full | Full-scale numerical simulation of hemodynamics based on left ventricular assist device |
title_fullStr | Full-scale numerical simulation of hemodynamics based on left ventricular assist device |
title_full_unstemmed | Full-scale numerical simulation of hemodynamics based on left ventricular assist device |
title_short | Full-scale numerical simulation of hemodynamics based on left ventricular assist device |
title_sort | full-scale numerical simulation of hemodynamics based on left ventricular assist device |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248007/ https://www.ncbi.nlm.nih.gov/pubmed/37304828 http://dx.doi.org/10.3389/fphys.2023.1192610 |
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