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Full-scale numerical simulation of hemodynamics based on left ventricular assist device

Ventricular assist devices have been widely used and accepted to treat patients with end-stage heart failure. The role of VAD is to improve circulatory dysfunction or temporarily maintain the circulatory status of patients. In order to be closer to the medical practice, a multi-Domain model of the l...

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Autores principales: Gao, Xinyi, Xu, Zhike, Chen, Chenghan, Hao, Pengfei, He, Feng, Zhang, Xiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248007/
https://www.ncbi.nlm.nih.gov/pubmed/37304828
http://dx.doi.org/10.3389/fphys.2023.1192610
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author Gao, Xinyi
Xu, Zhike
Chen, Chenghan
Hao, Pengfei
He, Feng
Zhang, Xiwen
author_facet Gao, Xinyi
Xu, Zhike
Chen, Chenghan
Hao, Pengfei
He, Feng
Zhang, Xiwen
author_sort Gao, Xinyi
collection PubMed
description Ventricular assist devices have been widely used and accepted to treat patients with end-stage heart failure. The role of VAD is to improve circulatory dysfunction or temporarily maintain the circulatory status of patients. In order to be closer to the medical practice, a multi-Domain model of the left ventricular coupled axial flow artificial heart was considered to study the effect of its hemodynamics on the aorta. Because whether LVAD itself was connected between the left ventricular apex and the ascending aorta by catheter in the loop was not very important for the analysis of simulation results, on the premise of ensuring the multi-Domain simulation, the simulation data of the import and export ends of LVAD were imported to simplify the model. In this paper, the hemodynamic parameters in the ascending aorta, such as blood flow velocity vector, wall shear stress distribution, vorticity current intensity, vorticity flow generation, etc., have been calculated. The numerical conclusion of this study showed the vorticity intensity under LVAD was significantly higher than that under patients’ conditions and the overall condition is similar to that of a healthy ventricular spin, which can improve heart failure patients’ condition while minimizing other pitfalls. In addition, high velocity blood flow during left ventricular assist surgery is mainly concentrated near the lining of the ascending aorta lumen. What’s more, the paper proposes to use Q criterion to determine the generation of vorticity flow. The Q criterion of LVAD is much higher than that of patients with heart failure, and the closer the LVAD is to the wall of the ascending aorta, the greater the Q criterion is. All these are beneficial to the effectiveness of LVAD in the treatment of heart failure patients and provide clinical suggestions for the LVAD implantation in clinical practice.
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spelling pubmed-102480072023-06-09 Full-scale numerical simulation of hemodynamics based on left ventricular assist device Gao, Xinyi Xu, Zhike Chen, Chenghan Hao, Pengfei He, Feng Zhang, Xiwen Front Physiol Physiology Ventricular assist devices have been widely used and accepted to treat patients with end-stage heart failure. The role of VAD is to improve circulatory dysfunction or temporarily maintain the circulatory status of patients. In order to be closer to the medical practice, a multi-Domain model of the left ventricular coupled axial flow artificial heart was considered to study the effect of its hemodynamics on the aorta. Because whether LVAD itself was connected between the left ventricular apex and the ascending aorta by catheter in the loop was not very important for the analysis of simulation results, on the premise of ensuring the multi-Domain simulation, the simulation data of the import and export ends of LVAD were imported to simplify the model. In this paper, the hemodynamic parameters in the ascending aorta, such as blood flow velocity vector, wall shear stress distribution, vorticity current intensity, vorticity flow generation, etc., have been calculated. The numerical conclusion of this study showed the vorticity intensity under LVAD was significantly higher than that under patients’ conditions and the overall condition is similar to that of a healthy ventricular spin, which can improve heart failure patients’ condition while minimizing other pitfalls. In addition, high velocity blood flow during left ventricular assist surgery is mainly concentrated near the lining of the ascending aorta lumen. What’s more, the paper proposes to use Q criterion to determine the generation of vorticity flow. The Q criterion of LVAD is much higher than that of patients with heart failure, and the closer the LVAD is to the wall of the ascending aorta, the greater the Q criterion is. All these are beneficial to the effectiveness of LVAD in the treatment of heart failure patients and provide clinical suggestions for the LVAD implantation in clinical practice. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10248007/ /pubmed/37304828 http://dx.doi.org/10.3389/fphys.2023.1192610 Text en Copyright © 2023 Gao, Xu, Chen, Hao, He and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Gao, Xinyi
Xu, Zhike
Chen, Chenghan
Hao, Pengfei
He, Feng
Zhang, Xiwen
Full-scale numerical simulation of hemodynamics based on left ventricular assist device
title Full-scale numerical simulation of hemodynamics based on left ventricular assist device
title_full Full-scale numerical simulation of hemodynamics based on left ventricular assist device
title_fullStr Full-scale numerical simulation of hemodynamics based on left ventricular assist device
title_full_unstemmed Full-scale numerical simulation of hemodynamics based on left ventricular assist device
title_short Full-scale numerical simulation of hemodynamics based on left ventricular assist device
title_sort full-scale numerical simulation of hemodynamics based on left ventricular assist device
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248007/
https://www.ncbi.nlm.nih.gov/pubmed/37304828
http://dx.doi.org/10.3389/fphys.2023.1192610
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