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Pan-cancer analysis reveals the prognostic and immunologic roles of cereblon and its significance for PROTAC design

BACKGROUND: Cereblon (CRBN) has emerged as a vital E3 ubiquitin ligase for Proteolysis-targeting chimera (PROTAC) design. However, few studies focus on the physiological mechanism of CRBN, and more studies are needed to explore the influence of CRBN on tumorigenesis. This pan-cancer analysis aims to...

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Detalles Bibliográficos
Autores principales:	Zhang, Si-Han, Zeng, Na, Sun, Jian-Xuan, Liu, Chen-Qian, Xu, Jin-Zhou, Xu, Meng-Yao, An, Ye, Zhong, Xing-Yu, Ma, Si-Yang, He, Hao-Dong, Xia, Qi-Dong, Hu, Jia, Wang, Shao-Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248115/ https://www.ncbi.nlm.nih.gov/pubmed/37303568 http://dx.doi.org/10.1016/j.heliyon.2023.e16644

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