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Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster

The development of high-throughput behavioral assays, where numerous individual animals can be analyzed in various experimental conditions, has facilitated the study of animal personality. Previous research showed that isogenic Drosophila melanogaster flies exhibit striking individual non-heritable...

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Autores principales: Krama, Tatjana, Munkevics, Māris, Krams, Ronalds, Grigorjeva, Tatjana, Trakimas, Giedrius, Jõers, Priit, Popovs, Sergejs, Zants, Krists, Elferts, Didzis, Rantala, Markus J., Sledevskis, Eriks, Contreras-Garduño, Jorge, de Bivort, Benjamin L., Krams, Indrikis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248140/
https://www.ncbi.nlm.nih.gov/pubmed/37304760
http://dx.doi.org/10.3389/fnbeh.2023.1189301
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author Krama, Tatjana
Munkevics, Māris
Krams, Ronalds
Grigorjeva, Tatjana
Trakimas, Giedrius
Jõers, Priit
Popovs, Sergejs
Zants, Krists
Elferts, Didzis
Rantala, Markus J.
Sledevskis, Eriks
Contreras-Garduño, Jorge
de Bivort, Benjamin L.
Krams, Indrikis A.
author_facet Krama, Tatjana
Munkevics, Māris
Krams, Ronalds
Grigorjeva, Tatjana
Trakimas, Giedrius
Jõers, Priit
Popovs, Sergejs
Zants, Krists
Elferts, Didzis
Rantala, Markus J.
Sledevskis, Eriks
Contreras-Garduño, Jorge
de Bivort, Benjamin L.
Krams, Indrikis A.
author_sort Krama, Tatjana
collection PubMed
description The development of high-throughput behavioral assays, where numerous individual animals can be analyzed in various experimental conditions, has facilitated the study of animal personality. Previous research showed that isogenic Drosophila melanogaster flies exhibit striking individual non-heritable locomotor handedness. The variability of this trait, i.e., the predictability of left-right turn biases, varies across genotypes and under the influence of neural activity in specific circuits. This suggests that the brain can dynamically regulate the extent of animal personality. It has been recently shown that predators can induce changes in prey phenotypes via lethal or non-lethal effects affecting the serotonergic signaling system. In this study, we tested whether fruit flies grown with predators exhibit higher variability/lower predictability in their turning behavior and higher survival than those grown with no predators in their environment. We confirmed these predictions and found that both effects were blocked when flies were fed an inhibitor (αMW) of serotonin synthesis. The results of this study demonstrate a negative association between the unpredictability of turning behavior of fruit flies and the hunting success of their predators. We also show that the neurotransmitter serotonin controls predator-induced changes in the turning variability of fruit flies, regulating the dynamic control of behavioral predictability.
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spelling pubmed-102481402023-06-09 Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster Krama, Tatjana Munkevics, Māris Krams, Ronalds Grigorjeva, Tatjana Trakimas, Giedrius Jõers, Priit Popovs, Sergejs Zants, Krists Elferts, Didzis Rantala, Markus J. Sledevskis, Eriks Contreras-Garduño, Jorge de Bivort, Benjamin L. Krams, Indrikis A. Front Behav Neurosci Neuroscience The development of high-throughput behavioral assays, where numerous individual animals can be analyzed in various experimental conditions, has facilitated the study of animal personality. Previous research showed that isogenic Drosophila melanogaster flies exhibit striking individual non-heritable locomotor handedness. The variability of this trait, i.e., the predictability of left-right turn biases, varies across genotypes and under the influence of neural activity in specific circuits. This suggests that the brain can dynamically regulate the extent of animal personality. It has been recently shown that predators can induce changes in prey phenotypes via lethal or non-lethal effects affecting the serotonergic signaling system. In this study, we tested whether fruit flies grown with predators exhibit higher variability/lower predictability in their turning behavior and higher survival than those grown with no predators in their environment. We confirmed these predictions and found that both effects were blocked when flies were fed an inhibitor (αMW) of serotonin synthesis. The results of this study demonstrate a negative association between the unpredictability of turning behavior of fruit flies and the hunting success of their predators. We also show that the neurotransmitter serotonin controls predator-induced changes in the turning variability of fruit flies, regulating the dynamic control of behavioral predictability. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10248140/ /pubmed/37304760 http://dx.doi.org/10.3389/fnbeh.2023.1189301 Text en Copyright © 2023 Krama, Munkevics, Krams, Grigorjeva, Trakimas, Jõers, Popovs, Zants, Elferts, Rantala, Sledevskis, Contreras-Garduño, de Bivort and Krams. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Krama, Tatjana
Munkevics, Māris
Krams, Ronalds
Grigorjeva, Tatjana
Trakimas, Giedrius
Jõers, Priit
Popovs, Sergejs
Zants, Krists
Elferts, Didzis
Rantala, Markus J.
Sledevskis, Eriks
Contreras-Garduño, Jorge
de Bivort, Benjamin L.
Krams, Indrikis A.
Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster
title Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster
title_full Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster
title_fullStr Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster
title_full_unstemmed Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster
title_short Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster
title_sort development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies drosophila melanogaster
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248140/
https://www.ncbi.nlm.nih.gov/pubmed/37304760
http://dx.doi.org/10.3389/fnbeh.2023.1189301
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