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A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis

Pulmonary tuberculosis is an inflammatory disease associated with an elevated cortisol/cortisone ratio at the site of infection and an array of cytokine changes. Tuberculous pericarditis is a less common but more lethal form of tuberculosis and has a similar inflammatory process in the pericardium....

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Autores principales: Shenje, Justin Tapiwa, Raubenheimer, Peter, Wiesner, Lubbe, Ross, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248178/
https://www.ncbi.nlm.nih.gov/pubmed/37305052
http://dx.doi.org/10.3389/fendo.2023.1127550
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author Shenje, Justin Tapiwa
Raubenheimer, Peter
Wiesner, Lubbe
Ross, Ian
author_facet Shenje, Justin Tapiwa
Raubenheimer, Peter
Wiesner, Lubbe
Ross, Ian
author_sort Shenje, Justin Tapiwa
collection PubMed
description Pulmonary tuberculosis is an inflammatory disease associated with an elevated cortisol/cortisone ratio at the site of infection and an array of cytokine changes. Tuberculous pericarditis is a less common but more lethal form of tuberculosis and has a similar inflammatory process in the pericardium. As the pericardium is largely inaccessible, the effect of tuberculous pericarditis on pericardial glucocorticoids is largely unknown. We wished to describe pericardial cortisolcortisone ratio in relation to plasma and saliva cortisol/cortisone ratios and the associated changes in cytokine concentrations. The median (interquartile range) of plasma, pericardial, and saliva cortisol concentration was 443 (379–532), 303 (257–384), and 20 (10–32) nmol/L, respectively, whereas the median (interquartile range) of plasma, pericardial, and saliva cortisone concentrations was 49 (35–57), 15.0 (0.0–21.7), and 37 (25–55) nmol/L, respectively. The cortisol/cortisone ratio was highest in pericardium with median (interquartile range) of 20 (13–445), followed by plasma of 9.1 (7.4–12.1) and saliva of 0.4 (0.3–0.8). The elevated cortisol/cortisone ratio was associated with elevated pericardial, interferon gamma, tumor necrosis factor–alpha, interleukin-6, interleukin-8, and induced protein 10. Administration of a single dose of 120 mg of prednisolone was associated with the suppression of pericardial cortisol and cortisone within 24 h of administration. The cortisol/cortisone ratio was highest at the site of infection, in this case, the pericardium. The elevated ratio was associated with a differential cytokine response. The observed pericardial cortisol suppression suggests that 120 mg of prednisolone was sufficient to evoke an immunomodulatory effect in the pericardium.
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spelling pubmed-102481782023-06-09 A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis Shenje, Justin Tapiwa Raubenheimer, Peter Wiesner, Lubbe Ross, Ian Front Endocrinol (Lausanne) Endocrinology Pulmonary tuberculosis is an inflammatory disease associated with an elevated cortisol/cortisone ratio at the site of infection and an array of cytokine changes. Tuberculous pericarditis is a less common but more lethal form of tuberculosis and has a similar inflammatory process in the pericardium. As the pericardium is largely inaccessible, the effect of tuberculous pericarditis on pericardial glucocorticoids is largely unknown. We wished to describe pericardial cortisolcortisone ratio in relation to plasma and saliva cortisol/cortisone ratios and the associated changes in cytokine concentrations. The median (interquartile range) of plasma, pericardial, and saliva cortisol concentration was 443 (379–532), 303 (257–384), and 20 (10–32) nmol/L, respectively, whereas the median (interquartile range) of plasma, pericardial, and saliva cortisone concentrations was 49 (35–57), 15.0 (0.0–21.7), and 37 (25–55) nmol/L, respectively. The cortisol/cortisone ratio was highest in pericardium with median (interquartile range) of 20 (13–445), followed by plasma of 9.1 (7.4–12.1) and saliva of 0.4 (0.3–0.8). The elevated cortisol/cortisone ratio was associated with elevated pericardial, interferon gamma, tumor necrosis factor–alpha, interleukin-6, interleukin-8, and induced protein 10. Administration of a single dose of 120 mg of prednisolone was associated with the suppression of pericardial cortisol and cortisone within 24 h of administration. The cortisol/cortisone ratio was highest at the site of infection, in this case, the pericardium. The elevated ratio was associated with a differential cytokine response. The observed pericardial cortisol suppression suggests that 120 mg of prednisolone was sufficient to evoke an immunomodulatory effect in the pericardium. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10248178/ /pubmed/37305052 http://dx.doi.org/10.3389/fendo.2023.1127550 Text en Copyright © 2023 Shenje, Raubenheimer, Wiesner and Ross https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Shenje, Justin Tapiwa
Raubenheimer, Peter
Wiesner, Lubbe
Ross, Ian
A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis
title A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis
title_full A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis
title_fullStr A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis
title_full_unstemmed A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis
title_short A description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis
title_sort description of the elevation of pericardial cortisol: cortisone ratio in patients with tuberculous pericarditis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248178/
https://www.ncbi.nlm.nih.gov/pubmed/37305052
http://dx.doi.org/10.3389/fendo.2023.1127550
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