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Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation
KEY CLINICAL MESSAGE: Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment. When anticoagulation therapy is...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248206/ https://www.ncbi.nlm.nih.gov/pubmed/37305887 http://dx.doi.org/10.1002/ccr3.7284 |
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author | Frydrysiak, Marlena Pachniak, Paulina Krysicka, Anna Moczulski, Dariusz |
author_facet | Frydrysiak, Marlena Pachniak, Paulina Krysicka, Anna Moczulski, Dariusz |
author_sort | Frydrysiak, Marlena |
collection | PubMed |
description | KEY CLINICAL MESSAGE: Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment. When anticoagulation therapy is needed vitamin K antagonist are a good option for the initial treatment. ABSTRACT: Lupus anticoagulant antibodies despite causing aPTT prolongation are commonly associated with increased risk of thrombosis. We present a rare case of patient when these autoantibodies resulted in dramatic aPTT prolongation and combined with associated thrombocytopenia resulted in minor bleeding events. In presented case treatment with oral steroids resulted in aPTT values correction followed by resolution of bleeding tendency within several days. Later, the patient developed chronic atrial fibrillation and was started on anticoagulation treatment initially with vitamin K antagonist without bleeding complications during follow‐up period. Corresponding changes in patient's aPTT time in a course of whole treatment is presented. |
format | Online Article Text |
id | pubmed-10248206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102482062023-06-09 Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation Frydrysiak, Marlena Pachniak, Paulina Krysicka, Anna Moczulski, Dariusz Clin Case Rep Case Report KEY CLINICAL MESSAGE: Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment. When anticoagulation therapy is needed vitamin K antagonist are a good option for the initial treatment. ABSTRACT: Lupus anticoagulant antibodies despite causing aPTT prolongation are commonly associated with increased risk of thrombosis. We present a rare case of patient when these autoantibodies resulted in dramatic aPTT prolongation and combined with associated thrombocytopenia resulted in minor bleeding events. In presented case treatment with oral steroids resulted in aPTT values correction followed by resolution of bleeding tendency within several days. Later, the patient developed chronic atrial fibrillation and was started on anticoagulation treatment initially with vitamin K antagonist without bleeding complications during follow‐up period. Corresponding changes in patient's aPTT time in a course of whole treatment is presented. John Wiley and Sons Inc. 2023-06-07 /pmc/articles/PMC10248206/ /pubmed/37305887 http://dx.doi.org/10.1002/ccr3.7284 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Frydrysiak, Marlena Pachniak, Paulina Krysicka, Anna Moczulski, Dariusz Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
title | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
title_full | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
title_fullStr | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
title_full_unstemmed | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
title_short | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
title_sort | patient with lupus anticoagulant caused aptt prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248206/ https://www.ncbi.nlm.nih.gov/pubmed/37305887 http://dx.doi.org/10.1002/ccr3.7284 |
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