Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review

KEY CLINICAL MESSAGE: We report the first case of pathologic complete response (pCR) to neoadjuvant imatinib in a gastric stromal tumor harboring KIT mutations in both exons 11 and 9. The significance of this co‐occurrence is unknown and might increase the responsiveness of gastrointestinal stromal...

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Autores principales: Rekaya, Mariem Ben, Ksontini, Feryel, Kacem, Linda Bel Haj, Sassi, Farah, Harigua‐Souiai, Emna, Boujneh, Ryma, H'mayada, Ahmed, Zaimi, Yosra, Ayadi, Mouna, Trabelsi, Mediha, Mrad, Ridha, Rammeh, Soumaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248213/
https://www.ncbi.nlm.nih.gov/pubmed/37305871
http://dx.doi.org/10.1002/ccr3.7463
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author Rekaya, Mariem Ben
Ksontini, Feryel
Kacem, Linda Bel Haj
Sassi, Farah
Harigua‐Souiai, Emna
Boujneh, Ryma
H'mayada, Ahmed
Zaimi, Yosra
Ayadi, Mouna
Trabelsi, Mediha
Mrad, Ridha
Rammeh, Soumaya
author_facet Rekaya, Mariem Ben
Ksontini, Feryel
Kacem, Linda Bel Haj
Sassi, Farah
Harigua‐Souiai, Emna
Boujneh, Ryma
H'mayada, Ahmed
Zaimi, Yosra
Ayadi, Mouna
Trabelsi, Mediha
Mrad, Ridha
Rammeh, Soumaya
author_sort Rekaya, Mariem Ben
collection PubMed
description KEY CLINICAL MESSAGE: We report the first case of pathologic complete response (pCR) to neoadjuvant imatinib in a gastric stromal tumor harboring KIT mutations in both exons 11 and 9. The significance of this co‐occurrence is unknown and might increase the responsiveness of gastrointestinal stromal tumors (GISTs) to imatinib. ABSTRACT: pCR of GIST to neoadjuvant imatinib is rare. We report a case of pCR to neoadjuvant imatinib in a gastric stromal tumor that harbored co‐occurrence of multiple KIT mutations in exons 11 and 9. This co‐occurrence in exons 9 and 11 is the first to be reported in the English literature.
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spelling pubmed-102482132023-06-09 Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review Rekaya, Mariem Ben Ksontini, Feryel Kacem, Linda Bel Haj Sassi, Farah Harigua‐Souiai, Emna Boujneh, Ryma H'mayada, Ahmed Zaimi, Yosra Ayadi, Mouna Trabelsi, Mediha Mrad, Ridha Rammeh, Soumaya Clin Case Rep Case Report KEY CLINICAL MESSAGE: We report the first case of pathologic complete response (pCR) to neoadjuvant imatinib in a gastric stromal tumor harboring KIT mutations in both exons 11 and 9. The significance of this co‐occurrence is unknown and might increase the responsiveness of gastrointestinal stromal tumors (GISTs) to imatinib. ABSTRACT: pCR of GIST to neoadjuvant imatinib is rare. We report a case of pCR to neoadjuvant imatinib in a gastric stromal tumor that harbored co‐occurrence of multiple KIT mutations in exons 11 and 9. This co‐occurrence in exons 9 and 11 is the first to be reported in the English literature. John Wiley and Sons Inc. 2023-06-07 /pmc/articles/PMC10248213/ /pubmed/37305871 http://dx.doi.org/10.1002/ccr3.7463 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Rekaya, Mariem Ben
Ksontini, Feryel
Kacem, Linda Bel Haj
Sassi, Farah
Harigua‐Souiai, Emna
Boujneh, Ryma
H'mayada, Ahmed
Zaimi, Yosra
Ayadi, Mouna
Trabelsi, Mediha
Mrad, Ridha
Rammeh, Soumaya
Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review
title Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review
title_full Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review
title_fullStr Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review
title_full_unstemmed Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review
title_short Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in KIT : A case report and literature review
title_sort pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in kit : a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248213/
https://www.ncbi.nlm.nih.gov/pubmed/37305871
http://dx.doi.org/10.1002/ccr3.7463
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