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Targeting the autophagy-lysosomal pathway in Huntington disease: a pharmacological perspective

The autophagy-lysosomal pathway (ALP) is the major biological pathway responsible for clearing intracellular protein aggregates, therefore a promising target for treating diseases featuring the accumulation of aggregation-prone proteins, such as Huntington disease (HD). However, accumulating evidenc...

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Detalles Bibliográficos
Autores principales: Yang, Junsheng, Zhang, Chaoyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248240/
https://www.ncbi.nlm.nih.gov/pubmed/37304076
http://dx.doi.org/10.3389/fnagi.2023.1175598