A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment

Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The investigation aimed to assess the effects of STN-DBS on cocaine cra...

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Autores principales: Vorspan, Florence, Domenech, Philippe, Grabli, David, Yelnik, Jérôme, Delavest, Marine, Dauré, Charles, Bellivier, Frank, Pelissolo, Antoine, Belaid, Hayat, Baunez, Christelle, Karachi, Carine, Mallet, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248431/
https://www.ncbi.nlm.nih.gov/pubmed/37304434
http://dx.doi.org/10.3389/fpsyt.2023.1146492
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author Vorspan, Florence
Domenech, Philippe
Grabli, David
Yelnik, Jérôme
Delavest, Marine
Dauré, Charles
Bellivier, Frank
Pelissolo, Antoine
Belaid, Hayat
Baunez, Christelle
Karachi, Carine
Mallet, Luc
author_facet Vorspan, Florence
Domenech, Philippe
Grabli, David
Yelnik, Jérôme
Delavest, Marine
Dauré, Charles
Bellivier, Frank
Pelissolo, Antoine
Belaid, Hayat
Baunez, Christelle
Karachi, Carine
Mallet, Luc
author_sort Vorspan, Florence
collection PubMed
description Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The investigation aimed to assess the effects of STN-DBS on cocaine craving and cocaine use, as well as STN-DBS safety and tolerance in this indication. In this pilot study, we performed double blind cross-over trials, with “ON-DBS” vs. “SHAM-DBS” for 1-month periods. STN-DBS failed to reduce cocaine craving and use. An episode of DBS-induced hypomania occurred after several weeks of cocaine intake at stimulation parameters previously well tolerated. Future research on cocaine dependence should be conducted after a prolonged abstinence period and/or explore novel types of stimulation patterns.
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spelling pubmed-102484312023-06-09 A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment Vorspan, Florence Domenech, Philippe Grabli, David Yelnik, Jérôme Delavest, Marine Dauré, Charles Bellivier, Frank Pelissolo, Antoine Belaid, Hayat Baunez, Christelle Karachi, Carine Mallet, Luc Front Psychiatry Psychiatry Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The investigation aimed to assess the effects of STN-DBS on cocaine craving and cocaine use, as well as STN-DBS safety and tolerance in this indication. In this pilot study, we performed double blind cross-over trials, with “ON-DBS” vs. “SHAM-DBS” for 1-month periods. STN-DBS failed to reduce cocaine craving and use. An episode of DBS-induced hypomania occurred after several weeks of cocaine intake at stimulation parameters previously well tolerated. Future research on cocaine dependence should be conducted after a prolonged abstinence period and/or explore novel types of stimulation patterns. Frontiers Media S.A. 2023-05-25 /pmc/articles/PMC10248431/ /pubmed/37304434 http://dx.doi.org/10.3389/fpsyt.2023.1146492 Text en Copyright © 2023 Vorspan, Domenech, Grabli, Yelnik, Delavest, Dauré, Bellivier, Pelissolo, Belaid, Baunez, Karachi and Mallet. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Vorspan, Florence
Domenech, Philippe
Grabli, David
Yelnik, Jérôme
Delavest, Marine
Dauré, Charles
Bellivier, Frank
Pelissolo, Antoine
Belaid, Hayat
Baunez, Christelle
Karachi, Carine
Mallet, Luc
A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment
title A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment
title_full A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment
title_fullStr A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment
title_full_unstemmed A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment
title_short A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment
title_sort single case report of stn-dbs for severe crack-cocaine dependence: double-blind on vs. sham randomized controlled assessment
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248431/
https://www.ncbi.nlm.nih.gov/pubmed/37304434
http://dx.doi.org/10.3389/fpsyt.2023.1146492
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