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Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression

INTRODUCTION: The co-regulatory molecule, HVEM, can stimulate or inhibit immune function, but when co-expressed with BTLA, forms an inert complex preventing signaling. Altered HVEM or BTLA expression, separately have been associated with increased nosocomial infections in critical illness. Given tha...

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Detalles Bibliográficos
Autores principales:	Wakeley, Michelle E., Armstead, Brandon E., Gray, Chyna C., Tindal, Elizabeth W., Heffernan, Daithi S., Chung, Chun-Shiang, Ayala, Alfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248445/ https://www.ncbi.nlm.nih.gov/pubmed/37305124 http://dx.doi.org/10.3389/fmed.2023.1176602

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