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Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review

BACKGROUND: Primary spinal anaplastic meningioma (PSAM) is a very rare entity in the spinal canal. Therefore, the clinical features, treatment strategy, and long-term outcomes remain poorly studied. CASE DESCRIPTION: Clinical data of six patients with PSAM treated at one single institution were retr...

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Autores principales: Wu, Liang, Wang, Li’ao, Zou, Wanjing, Yang, Jun, Jia, Wenqing, Xu, Yulun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248570/
https://www.ncbi.nlm.nih.gov/pubmed/37304540
http://dx.doi.org/10.21037/tcr-22-2505
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author Wu, Liang
Wang, Li’ao
Zou, Wanjing
Yang, Jun
Jia, Wenqing
Xu, Yulun
author_facet Wu, Liang
Wang, Li’ao
Zou, Wanjing
Yang, Jun
Jia, Wenqing
Xu, Yulun
author_sort Wu, Liang
collection PubMed
description BACKGROUND: Primary spinal anaplastic meningioma (PSAM) is a very rare entity in the spinal canal. Therefore, the clinical features, treatment strategy, and long-term outcomes remain poorly studied. CASE DESCRIPTION: Clinical data of six patients with PSAM treated at one single institution were retrospectively analyzed and all previously reported cases in the English literature were reviewed. There were three male and three female patients with a median age of 25 years. The duration of symptoms before initial diagnosis ranged from one week to one year. PSAMs occurred at cervical level in four, cervicothoracic in one and thoracolumbar in one. In addition, PSAMs presented isointensity on T1 weighted imaging (WI), hyperintensity on T2WI, and hetero- or homogeneously marked enhancement with contrast. Eight operations were performed in six patients. Simpson II resection was achieved in four (50%), Simpson IV in three (37.5%), Simpson V in one (12.5%). Adjuvant radiotherapy was performed in five patients. With a median survival time of 14 months (4–136 months), three patients had recurrence, two experienced metastases, and four died of respiratory failure. CONCLUSIONS: PSAMs are a rare disease, and there is limited evidence as to the management of these lesions. They may metastasize, recur, and portend a poor prognosis. A close follow-up and further investigation are therefore necessary.
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spelling pubmed-102485702023-06-09 Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review Wu, Liang Wang, Li’ao Zou, Wanjing Yang, Jun Jia, Wenqing Xu, Yulun Transl Cancer Res Case Series BACKGROUND: Primary spinal anaplastic meningioma (PSAM) is a very rare entity in the spinal canal. Therefore, the clinical features, treatment strategy, and long-term outcomes remain poorly studied. CASE DESCRIPTION: Clinical data of six patients with PSAM treated at one single institution were retrospectively analyzed and all previously reported cases in the English literature were reviewed. There were three male and three female patients with a median age of 25 years. The duration of symptoms before initial diagnosis ranged from one week to one year. PSAMs occurred at cervical level in four, cervicothoracic in one and thoracolumbar in one. In addition, PSAMs presented isointensity on T1 weighted imaging (WI), hyperintensity on T2WI, and hetero- or homogeneously marked enhancement with contrast. Eight operations were performed in six patients. Simpson II resection was achieved in four (50%), Simpson IV in three (37.5%), Simpson V in one (12.5%). Adjuvant radiotherapy was performed in five patients. With a median survival time of 14 months (4–136 months), three patients had recurrence, two experienced metastases, and four died of respiratory failure. CONCLUSIONS: PSAMs are a rare disease, and there is limited evidence as to the management of these lesions. They may metastasize, recur, and portend a poor prognosis. A close follow-up and further investigation are therefore necessary. AME Publishing Company 2023-04-07 2023-05-31 /pmc/articles/PMC10248570/ /pubmed/37304540 http://dx.doi.org/10.21037/tcr-22-2505 Text en 2023 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Case Series
Wu, Liang
Wang, Li’ao
Zou, Wanjing
Yang, Jun
Jia, Wenqing
Xu, Yulun
Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review
title Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review
title_full Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review
title_fullStr Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review
title_full_unstemmed Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review
title_short Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review
title_sort clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248570/
https://www.ncbi.nlm.nih.gov/pubmed/37304540
http://dx.doi.org/10.21037/tcr-22-2505
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