Cargando…
Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial
BACKGROUND: Obsessive-compulsive disorder (OCD) is a common and chronic mental illness with a high rate of disability. Internet-based cognitive behavioral therapy (ICBT) makes online treatment available to patients and has been shown to be effective. However, 3-arm trials on ICBT, face-to-face cogni...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JMIR Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248767/ https://www.ncbi.nlm.nih.gov/pubmed/37223977 http://dx.doi.org/10.2196/41283 |
_version_ | 1785055423562252288 |
---|---|
author | Wu, Yiwen Li, Xin Zhou, Yuxin Gao, Rui Wang, Kaifeng Ye, Huiling Lyu, Na Wang, Chun Zhang, Ning Wang, Zhen Fan, Qing |
author_facet | Wu, Yiwen Li, Xin Zhou, Yuxin Gao, Rui Wang, Kaifeng Ye, Huiling Lyu, Na Wang, Chun Zhang, Ning Wang, Zhen Fan, Qing |
author_sort | Wu, Yiwen |
collection | PubMed |
description | BACKGROUND: Obsessive-compulsive disorder (OCD) is a common and chronic mental illness with a high rate of disability. Internet-based cognitive behavioral therapy (ICBT) makes online treatment available to patients and has been shown to be effective. However, 3-arm trials on ICBT, face-to-face cognitive behavioral group therapy (CBGT), and only medication are still lacking. OBJECTIVE: This study is a randomized, controlled, assessor-blinded trial of 3 groups for OCD: ICBT combined with medication, CBGT combined with medication, and conventional medical treatment (ie, treatment as usual [TAU]). The study aims to investigate the efficacy and cost-effectiveness of ICBT related to CBGT and TAU for adults with OCD in China. METHODS: In total, 99 patients with OCD were selected and randomly assigned to the ICBT, CBGT, and TAU groups for treatment for 6 weeks. The primary outcomes were the Yale-Brown Obsessive-Compulsive Scale (YBOCS) and the self-rating Florida Obsessive-Compulsive Inventory (FOCI), compared at baseline, during treatment (3 weeks), and after treatment (6 weeks), to analyze efficacy. The secondary outcome was the EuroQol Visual Analogue Scale (EQ-VAS) scores of the EuroQol 5D Questionnaire (EQ-5D). The cost questionnaires were recorded to analyze cost-effectiveness. RESULTS: Repeated-measures ANOVA was used for data analysis, and the final effective sample size was 93 (ICBT: n=32, 34.4%; CBGT: n=28, 30.1%; TAU: n=33, 35.5%). After 6-week treatment, the YBOCS scores of the 3 groups significantly decreased (P<.001), and there were no significant differences among groups. The FOCI score of the ICBT (P=.001) and CBGT (P=.035) groups was significantly lower than that of the TAU group after treatment. The total cost of the CBGT group (renminbi [RMB] 6678.45, 95% CI 4460.88-8896.01 [US $1010.36, 95% CI 678.87-1345.84]) was significantly higher than that of the ICBT group (RMB 3308.81, 95% CI 2476.89-4140.73[US $500.58, 95% CI 374.72-626.43], P<.001) and the TAU group (RMB 2259.61, 95% CI 2074.16-2445.05 [US $341.85, 95% CI 313.79-369.90], P<.001) after treatment. The ICBT group spent RMB 303.19 (US $45.97) less than the CBGT group and RMB 11.57 (US $1.75) less than the TAU group for each unit reduction in the YBOCS score. CONCLUSIONS: Therapist-guided ICBT combined with medication is as effective as face-to-face CBGT combined with medication for OCD. ICBT combined with medication is more cost-effective than CBGT combined with medication and conventional medical treatment. It is expected to become an efficacious and economic alternative for adults with OCD when face-to-face CBGT is not available. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR1900023840; https://www.chictr.org.cn/showproj.html?proj=39294 |
format | Online Article Text |
id | pubmed-10248767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | JMIR Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-102487672023-06-09 Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial Wu, Yiwen Li, Xin Zhou, Yuxin Gao, Rui Wang, Kaifeng Ye, Huiling Lyu, Na Wang, Chun Zhang, Ning Wang, Zhen Fan, Qing J Med Internet Res Original Paper BACKGROUND: Obsessive-compulsive disorder (OCD) is a common and chronic mental illness with a high rate of disability. Internet-based cognitive behavioral therapy (ICBT) makes online treatment available to patients and has been shown to be effective. However, 3-arm trials on ICBT, face-to-face cognitive behavioral group therapy (CBGT), and only medication are still lacking. OBJECTIVE: This study is a randomized, controlled, assessor-blinded trial of 3 groups for OCD: ICBT combined with medication, CBGT combined with medication, and conventional medical treatment (ie, treatment as usual [TAU]). The study aims to investigate the efficacy and cost-effectiveness of ICBT related to CBGT and TAU for adults with OCD in China. METHODS: In total, 99 patients with OCD were selected and randomly assigned to the ICBT, CBGT, and TAU groups for treatment for 6 weeks. The primary outcomes were the Yale-Brown Obsessive-Compulsive Scale (YBOCS) and the self-rating Florida Obsessive-Compulsive Inventory (FOCI), compared at baseline, during treatment (3 weeks), and after treatment (6 weeks), to analyze efficacy. The secondary outcome was the EuroQol Visual Analogue Scale (EQ-VAS) scores of the EuroQol 5D Questionnaire (EQ-5D). The cost questionnaires were recorded to analyze cost-effectiveness. RESULTS: Repeated-measures ANOVA was used for data analysis, and the final effective sample size was 93 (ICBT: n=32, 34.4%; CBGT: n=28, 30.1%; TAU: n=33, 35.5%). After 6-week treatment, the YBOCS scores of the 3 groups significantly decreased (P<.001), and there were no significant differences among groups. The FOCI score of the ICBT (P=.001) and CBGT (P=.035) groups was significantly lower than that of the TAU group after treatment. The total cost of the CBGT group (renminbi [RMB] 6678.45, 95% CI 4460.88-8896.01 [US $1010.36, 95% CI 678.87-1345.84]) was significantly higher than that of the ICBT group (RMB 3308.81, 95% CI 2476.89-4140.73[US $500.58, 95% CI 374.72-626.43], P<.001) and the TAU group (RMB 2259.61, 95% CI 2074.16-2445.05 [US $341.85, 95% CI 313.79-369.90], P<.001) after treatment. The ICBT group spent RMB 303.19 (US $45.97) less than the CBGT group and RMB 11.57 (US $1.75) less than the TAU group for each unit reduction in the YBOCS score. CONCLUSIONS: Therapist-guided ICBT combined with medication is as effective as face-to-face CBGT combined with medication for OCD. ICBT combined with medication is more cost-effective than CBGT combined with medication and conventional medical treatment. It is expected to become an efficacious and economic alternative for adults with OCD when face-to-face CBGT is not available. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR1900023840; https://www.chictr.org.cn/showproj.html?proj=39294 JMIR Publications 2023-05-24 /pmc/articles/PMC10248767/ /pubmed/37223977 http://dx.doi.org/10.2196/41283 Text en ©Yiwen Wu, Xin Li, Yuxin Zhou, Rui Gao, Kaifeng Wang, Huiling Ye, Na Lyu, Chun Wang, Ning Zhang, Zhen Wang, Qing Fan. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 24.05.2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included. |
spellingShingle | Original Paper Wu, Yiwen Li, Xin Zhou, Yuxin Gao, Rui Wang, Kaifeng Ye, Huiling Lyu, Na Wang, Chun Zhang, Ning Wang, Zhen Fan, Qing Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial |
title | Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial |
title_full | Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial |
title_fullStr | Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial |
title_full_unstemmed | Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial |
title_short | Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial |
title_sort | efficacy and cost-effectiveness analysis of internet-based cognitive behavioral therapy for obsessive-compulsive disorder: randomized controlled trial |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248767/ https://www.ncbi.nlm.nih.gov/pubmed/37223977 http://dx.doi.org/10.2196/41283 |
work_keys_str_mv | AT wuyiwen efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT lixin efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT zhouyuxin efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT gaorui efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT wangkaifeng efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT yehuiling efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT lyuna efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT wangchun efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT zhangning efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT wangzhen efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial AT fanqing efficacyandcosteffectivenessanalysisofinternetbasedcognitivebehavioraltherapyforobsessivecompulsivedisorderrandomizedcontrolledtrial |