Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy–linked E40K mutation

Canine degenerative myelopathy (DM), a fatal neurodegenerative disease in dogs, shares clinical and genetic features with amyotrophic lateral sclerosis, a human motor neuron disease. Mutations in the SOD1 gene encoding Cu/Zn superoxide dismutase (SOD1) cause canine DM and a subset of inherited human...

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Detalles Bibliográficos
Autores principales: Hashimoto, Kei, Watanabe, Seiji, Akutsu, Masato, Muraki, Norifumi, Kamishina, Hiroaki, Furukawa, Yoshiaki, Yamanaka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248865/
https://www.ncbi.nlm.nih.gov/pubmed/37156398
http://dx.doi.org/10.1016/j.jbc.2023.104798

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