PRMT1 methylates METTL14 to modulate its oncogenic function

N6-methyladenosine (m6A), the most abundant mRNA modification in mammalian cells, is responsible for mRNA stability and alternative splicing. The METTL3-METTL14-WTAP complex is the only methyltransferase for the m6A modification. Thus, regulation of its enzymatic activity is critical for the homeost...

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Detalles Bibliográficos
Autores principales: Wang, Jingchao, Wang, Zhen, Inuzuka, Hiroyuki, Wei, Wenyi, Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248872/
https://www.ncbi.nlm.nih.gov/pubmed/37269817
http://dx.doi.org/10.1016/j.neo.2023.100912

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