Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin(2) G protein–coupled receptor

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Adrenomedullin 2/intermedin (AM2/IMD), adrenomedullin (AM), and calcitonin gene-related peptide (CGRP) have functions in the cardiovascular, lymphatic, and nervous systems by activating three heterodimeric receptors comprising the class B GPCR CLR and a RAMP1, -2, or -3 modulatory subunit. CGRP and...

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Detalles Bibliográficos
Autores principales: Babin, Katie M., Karim, Jordan A., Gordon, Peyton H., Lennon, James, Dickson, Alex, Pioszak, Augen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248883/
https://www.ncbi.nlm.nih.gov/pubmed/37146967
http://dx.doi.org/10.1016/j.jbc.2023.104785
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