An exploration on retro-construction of plasma drug concentration-time curves from corresponding urine excretion data and single-point plasma concentrations using a simplified and idealized method

BACKGROUND: Despite the availability of various tools of modeling and simulation, clinical pediatric pharmacokinetic (PK) studies remain far less efficient than those on adults due to ethical constraints. One of the optimal solutions is to substitute urine to blood sampling based on explicit mathema...

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Detalles Bibliográficos
Autores principales: Li, Guanglu, Zhang, Wenpeng, Zhang, Meng, Xu, Jiamin, Zhu, Guanghua, Li, Jinglai, Luo, Huan, Zhuang, Xiaomei, Wang, Quanjun, Zhang, Tianhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248928/
https://www.ncbi.nlm.nih.gov/pubmed/37305729
http://dx.doi.org/10.21037/tp-22-505

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