Cargando…

Risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study

BACKGROUND: Complex febrile seizures are prolonged and can cause neurologic abnormalities, leading to secondary epilepsy and affecting growth and development. At present, the mechanism of secondary epilepsy in children with complex febrile seizures is not clear, and this study aimed to explore the r...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Meihua, Liao, Yaoqi, Guo, Huifang, Peng, Huangqing, Xia, Chunping, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248930/
https://www.ncbi.nlm.nih.gov/pubmed/37305715
http://dx.doi.org/10.21037/tp-23-203
_version_ 1785055453474979840
author Duan, Meihua
Liao, Yaoqi
Guo, Huifang
Peng, Huangqing
Xia, Chunping
Wang, Jing
author_facet Duan, Meihua
Liao, Yaoqi
Guo, Huifang
Peng, Huangqing
Xia, Chunping
Wang, Jing
author_sort Duan, Meihua
collection PubMed
description BACKGROUND: Complex febrile seizures are prolonged and can cause neurologic abnormalities, leading to secondary epilepsy and affecting growth and development. At present, the mechanism of secondary epilepsy in children with complex febrile seizures is not clear, and this study aimed to explore the risk factors for secondary epilepsy in children with complex febrile seizures and analyze its effects on the growth and development of children. METHODS: The data of 168 children with complex febrile seizures admitted to the Ganzhou Women and Children’s Health Care Hospital between January 2018 and December 2019 were collected retrospectively and divided into a secondary epilepsy group (n=58) and control group (n=110) according to whether the children had secondary epilepsy or not. The differences in clinical features between the 2 groups were compared, and logistic regression analysis was used to explore the risk factors for secondary epilepsy in children with complex febrile seizures. A nomogram prediction model for secondary epilepsy in children with complex febrile seizures was established and verified using the R 4.0.3 statistical software, and the effect of secondary epilepsy on the growth and development of children was analyzed. RESULTS: Multivariate logistic regression analysis showed that family history of epilepsy, generalized seizures, number of seizures, and duration of seizures were independent influencing factors of secondary epilepsy in children with complex febrile seizures (P<0.05). The dataset was randomly divided into a training set and a validation set, with a sample size of 84 in the training set and 84 in the validation set. The area under the receiver operating characteristic (ROC) curve of the training set was 0.845 (95% confidence interval: 0.756–0.934), and the area under the ROC curve of the validation set was 0.813 (95% confidence interval: 0.711–0.914). Compared with the control group, the Gesell Development Scale score in the secondary epilepsy group was significantly reduced (77.84±8.86 vs. 85.64±8.65, P<0.001). CONCLUSIONS: The nomogram prediction model could better identify complex febrile seizures children at high risk of secondary epilepsy. Strengthening intervention in such children may be beneficial for improving their growth and development.
format Online
Article
Text
id pubmed-10248930
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-102489302023-06-09 Risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study Duan, Meihua Liao, Yaoqi Guo, Huifang Peng, Huangqing Xia, Chunping Wang, Jing Transl Pediatr Original Article BACKGROUND: Complex febrile seizures are prolonged and can cause neurologic abnormalities, leading to secondary epilepsy and affecting growth and development. At present, the mechanism of secondary epilepsy in children with complex febrile seizures is not clear, and this study aimed to explore the risk factors for secondary epilepsy in children with complex febrile seizures and analyze its effects on the growth and development of children. METHODS: The data of 168 children with complex febrile seizures admitted to the Ganzhou Women and Children’s Health Care Hospital between January 2018 and December 2019 were collected retrospectively and divided into a secondary epilepsy group (n=58) and control group (n=110) according to whether the children had secondary epilepsy or not. The differences in clinical features between the 2 groups were compared, and logistic regression analysis was used to explore the risk factors for secondary epilepsy in children with complex febrile seizures. A nomogram prediction model for secondary epilepsy in children with complex febrile seizures was established and verified using the R 4.0.3 statistical software, and the effect of secondary epilepsy on the growth and development of children was analyzed. RESULTS: Multivariate logistic regression analysis showed that family history of epilepsy, generalized seizures, number of seizures, and duration of seizures were independent influencing factors of secondary epilepsy in children with complex febrile seizures (P<0.05). The dataset was randomly divided into a training set and a validation set, with a sample size of 84 in the training set and 84 in the validation set. The area under the receiver operating characteristic (ROC) curve of the training set was 0.845 (95% confidence interval: 0.756–0.934), and the area under the ROC curve of the validation set was 0.813 (95% confidence interval: 0.711–0.914). Compared with the control group, the Gesell Development Scale score in the secondary epilepsy group was significantly reduced (77.84±8.86 vs. 85.64±8.65, P<0.001). CONCLUSIONS: The nomogram prediction model could better identify complex febrile seizures children at high risk of secondary epilepsy. Strengthening intervention in such children may be beneficial for improving their growth and development. AME Publishing Company 2023-05-24 2023-05-30 /pmc/articles/PMC10248930/ /pubmed/37305715 http://dx.doi.org/10.21037/tp-23-203 Text en 2023 Translational Pediatrics. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Duan, Meihua
Liao, Yaoqi
Guo, Huifang
Peng, Huangqing
Xia, Chunping
Wang, Jing
Risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study
title Risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study
title_full Risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study
title_fullStr Risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study
title_full_unstemmed Risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study
title_short Risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study
title_sort risk factors for secondary epilepsy in children with complex febrile seizures and their effect on growth and development—a retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10248930/
https://www.ncbi.nlm.nih.gov/pubmed/37305715
http://dx.doi.org/10.21037/tp-23-203
work_keys_str_mv AT duanmeihua riskfactorsforsecondaryepilepsyinchildrenwithcomplexfebrileseizuresandtheireffectongrowthanddevelopmentaretrospectivecohortstudy
AT liaoyaoqi riskfactorsforsecondaryepilepsyinchildrenwithcomplexfebrileseizuresandtheireffectongrowthanddevelopmentaretrospectivecohortstudy
AT guohuifang riskfactorsforsecondaryepilepsyinchildrenwithcomplexfebrileseizuresandtheireffectongrowthanddevelopmentaretrospectivecohortstudy
AT penghuangqing riskfactorsforsecondaryepilepsyinchildrenwithcomplexfebrileseizuresandtheireffectongrowthanddevelopmentaretrospectivecohortstudy
AT xiachunping riskfactorsforsecondaryepilepsyinchildrenwithcomplexfebrileseizuresandtheireffectongrowthanddevelopmentaretrospectivecohortstudy
AT wangjing riskfactorsforsecondaryepilepsyinchildrenwithcomplexfebrileseizuresandtheireffectongrowthanddevelopmentaretrospectivecohortstudy