Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report

A 75-year-old man presented to our hospital with chronic sinusitis, bronchiectasis, and chronic lower respiratory tract infections. He began taking erythromycin in August, X-2. The chronic lower respiratory tract infection gradually worsened, and clarithromycin was started on May 11, X. He became aw...

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Detalles Bibliográficos
Autores principales: Nakano, Yoshio, Sekinada, Daisuke, Masuda, Gen, Nishio, Chihiro, Nishida, Koji, Okamoto, Norio, Gohma, Iwao, Esa, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249010/
https://www.ncbi.nlm.nih.gov/pubmed/37305218
http://dx.doi.org/10.1016/j.rmcr.2023.101878
Descripción
Sumario:A 75-year-old man presented to our hospital with chronic sinusitis, bronchiectasis, and chronic lower respiratory tract infections. He began taking erythromycin in August, X-2. The chronic lower respiratory tract infection gradually worsened, and clarithromycin was started on May 11, X. He became aware of fever and numbness in his lower legs on June 4, X. The sign occurred soon after oral clarithromycin and blood tests showed an elevated eosinophil count and C-reactive protein (CRP) levels, positive MPO-ANCA antibodies, and positive for drug-induced lymphocyte stimulation test (DLST); we diagnosed eosinophilic granulomatosis with polyangiitis (EGPA) associated with clarithromycin administration.

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