Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report

A 75-year-old man presented to our hospital with chronic sinusitis, bronchiectasis, and chronic lower respiratory tract infections. He began taking erythromycin in August, X-2. The chronic lower respiratory tract infection gradually worsened, and clarithromycin was started on May 11, X. He became aw...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakano, Yoshio, Sekinada, Daisuke, Masuda, Gen, Nishio, Chihiro, Nishida, Koji, Okamoto, Norio, Gohma, Iwao, Esa, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249010/
https://www.ncbi.nlm.nih.gov/pubmed/37305218
http://dx.doi.org/10.1016/j.rmcr.2023.101878
_version_ 1785055471582838784
author Nakano, Yoshio
Sekinada, Daisuke
Masuda, Gen
Nishio, Chihiro
Nishida, Koji
Okamoto, Norio
Gohma, Iwao
Esa, Yoshiki
author_facet Nakano, Yoshio
Sekinada, Daisuke
Masuda, Gen
Nishio, Chihiro
Nishida, Koji
Okamoto, Norio
Gohma, Iwao
Esa, Yoshiki
author_sort Nakano, Yoshio
collection PubMed
description A 75-year-old man presented to our hospital with chronic sinusitis, bronchiectasis, and chronic lower respiratory tract infections. He began taking erythromycin in August, X-2. The chronic lower respiratory tract infection gradually worsened, and clarithromycin was started on May 11, X. He became aware of fever and numbness in his lower legs on June 4, X. The sign occurred soon after oral clarithromycin and blood tests showed an elevated eosinophil count and C-reactive protein (CRP) levels, positive MPO-ANCA antibodies, and positive for drug-induced lymphocyte stimulation test (DLST); we diagnosed eosinophilic granulomatosis with polyangiitis (EGPA) associated with clarithromycin administration.
format Online
Article
Text
id pubmed-10249010
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-102490102023-06-09 Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report Nakano, Yoshio Sekinada, Daisuke Masuda, Gen Nishio, Chihiro Nishida, Koji Okamoto, Norio Gohma, Iwao Esa, Yoshiki Respir Med Case Rep Case Report A 75-year-old man presented to our hospital with chronic sinusitis, bronchiectasis, and chronic lower respiratory tract infections. He began taking erythromycin in August, X-2. The chronic lower respiratory tract infection gradually worsened, and clarithromycin was started on May 11, X. He became aware of fever and numbness in his lower legs on June 4, X. The sign occurred soon after oral clarithromycin and blood tests showed an elevated eosinophil count and C-reactive protein (CRP) levels, positive MPO-ANCA antibodies, and positive for drug-induced lymphocyte stimulation test (DLST); we diagnosed eosinophilic granulomatosis with polyangiitis (EGPA) associated with clarithromycin administration. Elsevier 2023-05-31 /pmc/articles/PMC10249010/ /pubmed/37305218 http://dx.doi.org/10.1016/j.rmcr.2023.101878 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakano, Yoshio
Sekinada, Daisuke
Masuda, Gen
Nishio, Chihiro
Nishida, Koji
Okamoto, Norio
Gohma, Iwao
Esa, Yoshiki
Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report
title Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report
title_full Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report
title_fullStr Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report
title_full_unstemmed Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report
title_short Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report
title_sort clarithromycin-induced eosinophilic granulomatosis with polyangiitis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249010/
https://www.ncbi.nlm.nih.gov/pubmed/37305218
http://dx.doi.org/10.1016/j.rmcr.2023.101878
work_keys_str_mv AT nakanoyoshio clarithromycininducedeosinophilicgranulomatosiswithpolyangiitisacasereport
AT sekinadadaisuke clarithromycininducedeosinophilicgranulomatosiswithpolyangiitisacasereport
AT masudagen clarithromycininducedeosinophilicgranulomatosiswithpolyangiitisacasereport
AT nishiochihiro clarithromycininducedeosinophilicgranulomatosiswithpolyangiitisacasereport
AT nishidakoji clarithromycininducedeosinophilicgranulomatosiswithpolyangiitisacasereport
AT okamotonorio clarithromycininducedeosinophilicgranulomatosiswithpolyangiitisacasereport
AT gohmaiwao clarithromycininducedeosinophilicgranulomatosiswithpolyangiitisacasereport
AT esayoshiki clarithromycininducedeosinophilicgranulomatosiswithpolyangiitisacasereport

Ejemplares similares