Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab

We present a case of a drug-induced sarcoidosis-like reaction (DISR) in a 34-year-old female patient who had been receiving dupilumab for eosinophilic rhinosinusitis, for seven months. Computerized tomography scans revealed multiple lymphadenopathies, and biopsies performed on the lung and skin lesi...

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Autores principales: Saito, Sho, Shimizu, Masamitsu, Miyashita, Ryota, Inoue, Tomoyasu, Nagano, Atushiro, Kunugi, Shinobu, Hatori, Tsutomu, Okano, Tetsuya, Seike, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249011/
https://www.ncbi.nlm.nih.gov/pubmed/37305219
http://dx.doi.org/10.1016/j.rmcr.2023.101883
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author Saito, Sho
Shimizu, Masamitsu
Miyashita, Ryota
Inoue, Tomoyasu
Nagano, Atushiro
Kunugi, Shinobu
Hatori, Tsutomu
Okano, Tetsuya
Seike, Masahiro
author_facet Saito, Sho
Shimizu, Masamitsu
Miyashita, Ryota
Inoue, Tomoyasu
Nagano, Atushiro
Kunugi, Shinobu
Hatori, Tsutomu
Okano, Tetsuya
Seike, Masahiro
author_sort Saito, Sho
collection PubMed
description We present a case of a drug-induced sarcoidosis-like reaction (DISR) in a 34-year-old female patient who had been receiving dupilumab for eosinophilic rhinosinusitis, for seven months. Computerized tomography scans revealed multiple lymphadenopathies, and biopsies performed on the lung and skin lesions showed the presence of non-caseating granulomas. The patient's serum levels of soluble interleukin-2 receptor and angiotensin-converting enzyme were elevated. There were no findings of Mycobacterium spp, or any other bacterial infections. Based on these findings, it was suspected that the sarcoidosis-like reaction observed in this patient was caused by dupilumab. Switching the patient's treatment from dupilumab to mepolizumab improved the DISR.
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spelling pubmed-102490112023-06-09 Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab Saito, Sho Shimizu, Masamitsu Miyashita, Ryota Inoue, Tomoyasu Nagano, Atushiro Kunugi, Shinobu Hatori, Tsutomu Okano, Tetsuya Seike, Masahiro Respir Med Case Rep Case Report We present a case of a drug-induced sarcoidosis-like reaction (DISR) in a 34-year-old female patient who had been receiving dupilumab for eosinophilic rhinosinusitis, for seven months. Computerized tomography scans revealed multiple lymphadenopathies, and biopsies performed on the lung and skin lesions showed the presence of non-caseating granulomas. The patient's serum levels of soluble interleukin-2 receptor and angiotensin-converting enzyme were elevated. There were no findings of Mycobacterium spp, or any other bacterial infections. Based on these findings, it was suspected that the sarcoidosis-like reaction observed in this patient was caused by dupilumab. Switching the patient's treatment from dupilumab to mepolizumab improved the DISR. Elsevier 2023-05-31 /pmc/articles/PMC10249011/ /pubmed/37305219 http://dx.doi.org/10.1016/j.rmcr.2023.101883 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Saito, Sho
Shimizu, Masamitsu
Miyashita, Ryota
Inoue, Tomoyasu
Nagano, Atushiro
Kunugi, Shinobu
Hatori, Tsutomu
Okano, Tetsuya
Seike, Masahiro
Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab
title Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab
title_full Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab
title_fullStr Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab
title_full_unstemmed Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab
title_short Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab
title_sort successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249011/
https://www.ncbi.nlm.nih.gov/pubmed/37305219
http://dx.doi.org/10.1016/j.rmcr.2023.101883
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