Cargando…
Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study
INTRODUCTION: The Kasabach–Merritt phenomenon (KMP) is a severe complication of kaposiform hemangioendothelioma (KHE). The risk factors for KMP need further investigation. METHODS: The medical records of patients with KHE were reviewed. Univariate and multivariate logistic regression models were use...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249050/ https://www.ncbi.nlm.nih.gov/pubmed/37305527 http://dx.doi.org/10.1093/pcmedi/pbad008 |
_version_ | 1785055478349299712 |
---|---|
author | Zhou, Jiangyuan Lan, Yuru Qiu, Tong Gong, Xue Zhang, Zixin He, Chunshui Peng, Qiang Hu, Fan Zhang, Xuepeng Lu, Guoyan Qiu, Liqing Kong, Feiteng Zhang, Yongbo Chen, Siyuan Ji, Yi |
author_facet | Zhou, Jiangyuan Lan, Yuru Qiu, Tong Gong, Xue Zhang, Zixin He, Chunshui Peng, Qiang Hu, Fan Zhang, Xuepeng Lu, Guoyan Qiu, Liqing Kong, Feiteng Zhang, Yongbo Chen, Siyuan Ji, Yi |
author_sort | Zhou, Jiangyuan |
collection | PubMed |
description | INTRODUCTION: The Kasabach–Merritt phenomenon (KMP) is a severe complication of kaposiform hemangioendothelioma (KHE). The risk factors for KMP need further investigation. METHODS: The medical records of patients with KHE were reviewed. Univariate and multivariate logistic regression models were used for the risk factors for KMP, and the area under the receiver operator characteristic (ROC) curve was used to assess the predictive power of risk factors. RESULTS: A total of 338 patients with KHE were enrolled. The incidence of KMP was 45.9%. Age of onset (P < 0.001, odds ratio [OR] 0.939; 95% confidence interval [CI] 0.914–0.966), lesion size (P < 0.001, OR 1.944; 95% CI 1.646–2.296), mixed type (P = 0.030, OR 2.428; 95% CI 1.092–5.397), deep type (P = 0.010, OR 4.006; 95% CI 1.389–11.556), and mediastinal or retroperitoneal lesion location (P = 0.019, OR 11.864; 95% CI 1.497–94.003) were correlated with KMP occurrence through multivariate logistic regression. ROC curve analysis revealed that the optimal cutoffs were 4.75 months for the age of onset (P < 0.001, OR 7.206, 95% CI 4.073–12.749) and a lesion diameter of 5.35 cm (P < 0.001, OR 11.817, 95% CI 7.084–19.714). Bounded by a lesion size of 5.35 cm, we found significant differences in tumor morphology, age of onset, treatments, and hematological parameters. Using an onset age of 4.75 months as a cutoff, we found significant differences in tumor morphology, lesion size, hematological parameters, and prognosis. CONCLUSION: For KHE patients with an onset age <4.75 months and/or lesion diameter >5.35 cm, clinicians should be wary of the occurrence of KMP. Active management is recommended to improve the prognosis. |
format | Online Article Text |
id | pubmed-10249050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-102490502023-06-09 Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study Zhou, Jiangyuan Lan, Yuru Qiu, Tong Gong, Xue Zhang, Zixin He, Chunshui Peng, Qiang Hu, Fan Zhang, Xuepeng Lu, Guoyan Qiu, Liqing Kong, Feiteng Zhang, Yongbo Chen, Siyuan Ji, Yi Precis Clin Med Research Article INTRODUCTION: The Kasabach–Merritt phenomenon (KMP) is a severe complication of kaposiform hemangioendothelioma (KHE). The risk factors for KMP need further investigation. METHODS: The medical records of patients with KHE were reviewed. Univariate and multivariate logistic regression models were used for the risk factors for KMP, and the area under the receiver operator characteristic (ROC) curve was used to assess the predictive power of risk factors. RESULTS: A total of 338 patients with KHE were enrolled. The incidence of KMP was 45.9%. Age of onset (P < 0.001, odds ratio [OR] 0.939; 95% confidence interval [CI] 0.914–0.966), lesion size (P < 0.001, OR 1.944; 95% CI 1.646–2.296), mixed type (P = 0.030, OR 2.428; 95% CI 1.092–5.397), deep type (P = 0.010, OR 4.006; 95% CI 1.389–11.556), and mediastinal or retroperitoneal lesion location (P = 0.019, OR 11.864; 95% CI 1.497–94.003) were correlated with KMP occurrence through multivariate logistic regression. ROC curve analysis revealed that the optimal cutoffs were 4.75 months for the age of onset (P < 0.001, OR 7.206, 95% CI 4.073–12.749) and a lesion diameter of 5.35 cm (P < 0.001, OR 11.817, 95% CI 7.084–19.714). Bounded by a lesion size of 5.35 cm, we found significant differences in tumor morphology, age of onset, treatments, and hematological parameters. Using an onset age of 4.75 months as a cutoff, we found significant differences in tumor morphology, lesion size, hematological parameters, and prognosis. CONCLUSION: For KHE patients with an onset age <4.75 months and/or lesion diameter >5.35 cm, clinicians should be wary of the occurrence of KMP. Active management is recommended to improve the prognosis. Oxford University Press 2023-05-19 /pmc/articles/PMC10249050/ /pubmed/37305527 http://dx.doi.org/10.1093/pcmedi/pbad008 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Research Article Zhou, Jiangyuan Lan, Yuru Qiu, Tong Gong, Xue Zhang, Zixin He, Chunshui Peng, Qiang Hu, Fan Zhang, Xuepeng Lu, Guoyan Qiu, Liqing Kong, Feiteng Zhang, Yongbo Chen, Siyuan Ji, Yi Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study |
title | Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study |
title_full | Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study |
title_fullStr | Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study |
title_full_unstemmed | Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study |
title_short | Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study |
title_sort | impact of age and tumor size on the development of the kasabach–merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249050/ https://www.ncbi.nlm.nih.gov/pubmed/37305527 http://dx.doi.org/10.1093/pcmedi/pbad008 |
work_keys_str_mv | AT zhoujiangyuan impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT lanyuru impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT qiutong impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT gongxue impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT zhangzixin impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT hechunshui impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT pengqiang impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT hufan impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT zhangxuepeng impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT luguoyan impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT qiuliqing impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT kongfeiteng impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT zhangyongbo impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT chensiyuan impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy AT jiyi impactofageandtumorsizeonthedevelopmentofthekasabachmerrittphenomenoninpatientswithkaposiformhemangioendotheliomaaretrospectivecohortstudy |