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Cyanopyridinone- and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation

[Image: see text] In this study, two new series of 3-cyanopyridinones (3a–e) and 3-cyanopyridines (4a–e) were synthesized and evaluated for their cytotoxicity and Pim-1 kinase inhibitory activity adopting 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and in vitro Pim-1 ki...

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Detalles Bibliográficos
Autores principales:	Mansour, Basem, Salem, Yomna A., Attallah, Khaled M., El-kawy, O. A., Ibrahim, Ismail T., Abdel-Aziz, Naglaa I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249106/ https://www.ncbi.nlm.nih.gov/pubmed/37305261 http://dx.doi.org/10.1021/acsomega.2c08304

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