The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer

The incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members...

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Autores principales: Asgharzadeh, Fereshteh, Moradi-Marjaneh, Reyhaneh, Marjaneh, Mahdi Moradi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249143/
https://www.ncbi.nlm.nih.gov/pubmed/35490324
http://dx.doi.org/10.2174/1381612828666220427140640
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author Asgharzadeh, Fereshteh
Moradi-Marjaneh, Reyhaneh
Marjaneh, Mahdi Moradi
author_facet Asgharzadeh, Fereshteh
Moradi-Marjaneh, Reyhaneh
Marjaneh, Mahdi Moradi
author_sort Asgharzadeh, Fereshteh
collection PubMed
description The incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of the Hsp family. It has attracted particular attention in CRC pathogenesis since it is involved in fundamental cell functions for cell survival. Evidence shows that Hsp27 plays important role in CRC progression and metastasis. Hsp27 overexpression has been observed in CRC and is suggested to be associated with CRC’s poor prognosis. In the present review, we focus on the current knowledge of the role of Hsp27 in CRC carcinogenesis and the underlying mechanisms. In addition, we discuss the value of targeting Hsp27 in CRC treatment.
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spelling pubmed-102491432023-06-09 The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer Asgharzadeh, Fereshteh Moradi-Marjaneh, Reyhaneh Marjaneh, Mahdi Moradi Curr Pharm Des Pharmacology The incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of the Hsp family. It has attracted particular attention in CRC pathogenesis since it is involved in fundamental cell functions for cell survival. Evidence shows that Hsp27 plays important role in CRC progression and metastasis. Hsp27 overexpression has been observed in CRC and is suggested to be associated with CRC’s poor prognosis. In the present review, we focus on the current knowledge of the role of Hsp27 in CRC carcinogenesis and the underlying mechanisms. In addition, we discuss the value of targeting Hsp27 in CRC treatment. Bentham Science Publishers 2022-10-19 2022-10-19 /pmc/articles/PMC10249143/ /pubmed/35490324 http://dx.doi.org/10.2174/1381612828666220427140640 Text en © 2022 Bentham Science Publishers https://creativecommons.org/licenses/by/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Pharmacology
Asgharzadeh, Fereshteh
Moradi-Marjaneh, Reyhaneh
Marjaneh, Mahdi Moradi
The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer
title The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer
title_full The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer
title_fullStr The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer
title_full_unstemmed The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer
title_short The Role of Heat Shock Protein 27 in Carcinogenesis and Treatment of Colorectal Cancer
title_sort role of heat shock protein 27 in carcinogenesis and treatment of colorectal cancer
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249143/
https://www.ncbi.nlm.nih.gov/pubmed/35490324
http://dx.doi.org/10.2174/1381612828666220427140640
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