Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells

BACKGROUND: Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besides, a mouse model of cholestasis-induced sarcopenia was characterised by incre...

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Detalles Bibliográficos
Autores principales: Abrigo, Johanna, Olguín, Hugo, Tacchi, Franco, Orozco-Aguilar, Josué, Valero-Breton, Mayalen, Soto, Jorge, Castro-Sepúlveda, Mauricio, Elorza, Alvaro A., Simon, Felipe, Cabello-Verrugio, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249330/
https://www.ncbi.nlm.nih.gov/pubmed/37291645
http://dx.doi.org/10.1186/s40659-023-00436-3

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