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Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond

Deficiency of selenium (Se) has been described in a significant number of COVID-19 patients having a higher incidence of mortality, which makes it a pertinent issue to be addressed clinically for effective management of the COVID-19 pandemic. Se nanoparticles (SeNPs) provide a unique option for mana...

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Autores principales: Khurana, Amit, Allawadhi, Prince, Singh, Vishakha, Khurana, Isha, Yadav, Poonam, Sathua, Kshirod Bihari, Allwadhi, Sachin, Banothu, Anil Kumar, Navik, Umashanker, Bharani, Kala Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249347/
https://www.ncbi.nlm.nih.gov/pubmed/37362903
http://dx.doi.org/10.1016/j.jddst.2023.104663
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author Khurana, Amit
Allawadhi, Prince
Singh, Vishakha
Khurana, Isha
Yadav, Poonam
Sathua, Kshirod Bihari
Allwadhi, Sachin
Banothu, Anil Kumar
Navik, Umashanker
Bharani, Kala Kumar
author_facet Khurana, Amit
Allawadhi, Prince
Singh, Vishakha
Khurana, Isha
Yadav, Poonam
Sathua, Kshirod Bihari
Allwadhi, Sachin
Banothu, Anil Kumar
Navik, Umashanker
Bharani, Kala Kumar
author_sort Khurana, Amit
collection PubMed
description Deficiency of selenium (Se) has been described in a significant number of COVID-19 patients having a higher incidence of mortality, which makes it a pertinent issue to be addressed clinically for effective management of the COVID-19 pandemic. Se nanoparticles (SeNPs) provide a unique option for managing the havoc caused by the COVID-19 pandemic. SeNPs possess promising anti-inflammatory and anti-fibrotic effects by virtue of their nuclear factor kappa-light-chain-stimulator of activated B cells (NFκB), mitogen-activated protein kinase (MAPKs), and transforming growth factor-beta (TGF-β) modulatory activity. In addition, SeNPs possess remarkable immunomodulatory effects, making them a suitable option for supplementation with a much lower risk of toxicity compared to their elemental counterpart. Further, SeNPs have been shown to curtail viral and microbial infections, thus, making it a novel means to halt viral growth. In addition, it can be administered in the form of aerosol spray, direct injection, or infused thin-film transdermal patches to reduce the spread of this highly contagious viral infection. Moreover, a considerable decrease in the expression of selenoprotein along with enhanced expression of IL-6 in COVID-19 suggests a potential association among selenoprotein expression and COVID-19. In this review, we highlight the unique antimicrobial and antiviral properties of SeNPs and the immunomodulatory potential of selenoproteins. We provide the rationale behind their potentially interesting properties and further exploration in the context of microbial and viral infections. Further, the importance of selenoproteins and their role in maintaining a successful immune response along with their association to Se status is summarized.
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spelling pubmed-102493472023-06-08 Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond Khurana, Amit Allawadhi, Prince Singh, Vishakha Khurana, Isha Yadav, Poonam Sathua, Kshirod Bihari Allwadhi, Sachin Banothu, Anil Kumar Navik, Umashanker Bharani, Kala Kumar J Drug Deliv Sci Technol Review Article Deficiency of selenium (Se) has been described in a significant number of COVID-19 patients having a higher incidence of mortality, which makes it a pertinent issue to be addressed clinically for effective management of the COVID-19 pandemic. Se nanoparticles (SeNPs) provide a unique option for managing the havoc caused by the COVID-19 pandemic. SeNPs possess promising anti-inflammatory and anti-fibrotic effects by virtue of their nuclear factor kappa-light-chain-stimulator of activated B cells (NFκB), mitogen-activated protein kinase (MAPKs), and transforming growth factor-beta (TGF-β) modulatory activity. In addition, SeNPs possess remarkable immunomodulatory effects, making them a suitable option for supplementation with a much lower risk of toxicity compared to their elemental counterpart. Further, SeNPs have been shown to curtail viral and microbial infections, thus, making it a novel means to halt viral growth. In addition, it can be administered in the form of aerosol spray, direct injection, or infused thin-film transdermal patches to reduce the spread of this highly contagious viral infection. Moreover, a considerable decrease in the expression of selenoprotein along with enhanced expression of IL-6 in COVID-19 suggests a potential association among selenoprotein expression and COVID-19. In this review, we highlight the unique antimicrobial and antiviral properties of SeNPs and the immunomodulatory potential of selenoproteins. We provide the rationale behind their potentially interesting properties and further exploration in the context of microbial and viral infections. Further, the importance of selenoproteins and their role in maintaining a successful immune response along with their association to Se status is summarized. Elsevier B.V. 2023-09 2023-06-08 /pmc/articles/PMC10249347/ /pubmed/37362903 http://dx.doi.org/10.1016/j.jddst.2023.104663 Text en © 2023 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Khurana, Amit
Allawadhi, Prince
Singh, Vishakha
Khurana, Isha
Yadav, Poonam
Sathua, Kshirod Bihari
Allwadhi, Sachin
Banothu, Anil Kumar
Navik, Umashanker
Bharani, Kala Kumar
Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond
title Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond
title_full Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond
title_fullStr Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond
title_full_unstemmed Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond
title_short Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond
title_sort antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: covid-19 and beyond
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249347/
https://www.ncbi.nlm.nih.gov/pubmed/37362903
http://dx.doi.org/10.1016/j.jddst.2023.104663
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