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Prion Protein Octarepeat Domain Forms Transient β-Sheet Structures upon Residue-Specific Binding to Cu(II) and Zn(II) Ions

[Image: see text] Misfolding of the cellular prion protein (PrP(C)) is associated with the development of fatal neurodegenerative diseases called transmissible spongiform encephalopathies (TSEs). Metal ions appear to play a crucial role in PrP(C) misfolding. PrP(C) is a combined Cu(II) and Zn(II) me...

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Detalles Bibliográficos
Autores principales:	Gielnik, Maciej, Szymańska, Aneta, Dong, Xiaolin, Jarvet, Jüri, Svedružić, Željko M., Gräslund, Astrid, Kozak, Maciej, Wärmländer, Sebastian K. T. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249355/ https://www.ncbi.nlm.nih.gov/pubmed/37163663 http://dx.doi.org/10.1021/acs.biochem.3c00129

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