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Phase II Single-Arm Study of Palbociclib and Cetuximab Rechallenge in Patients with KRAS/NRAS/BRAF Wild-Type Colorectal Cancer

BACKGROUND: Cetuximab is often administered to patients with KRAS wild-type (KRAS-WT) metastatic colorectal cancer (mCRC), although resistance inevitably develops. We hypothesized that co-inhibition of the epidermal growth factor receptor (EGFR) with cetuximab and downstream cyclin-dependent kinases...

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Detalles Bibliográficos
Autores principales:	Sorah, Jonathan D, Moore, Dominic T, Reilley, Matthew J, Salem, Mohamed E, Triglianos, Tammy, Sanoff, Hanna K, McRee, Autumn J, Lee, Michael S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Clinical Trial Results
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249423/ https://www.ncbi.nlm.nih.gov/pubmed/36288238 http://dx.doi.org/10.1093/oncolo/oyac222

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