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COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland

BACKGROUND: In manufacturers’ trials, vaccination against COVID-19 proved to be safe and effective. The officially reported frequency of vaccine adverse events (VAEs) in Poland is lower than that declared by the manufacturers. The anti-vaccination activists questioned the trustworthiness of official...

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Autores principales: Oleszczyk, Marek, Marciniak, Zuzanna, Nessler, Katarzyna, Wójtowicz, Ewa, Szozda, Nataliya, Kryj-Radziszewska, Elżbieta, Boroń, Maria, Gajos, Klaudia, Paziewski, Mateusz P., Sajdak, Paweł, Windak, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249448/
https://www.ncbi.nlm.nih.gov/pubmed/36469611
http://dx.doi.org/10.1080/13814788.2022.2147500
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author Oleszczyk, Marek
Marciniak, Zuzanna
Nessler, Katarzyna
Wójtowicz, Ewa
Szozda, Nataliya
Kryj-Radziszewska, Elżbieta
Boroń, Maria
Gajos, Klaudia
Paziewski, Mateusz P.
Sajdak, Paweł
Windak, Adam
author_facet Oleszczyk, Marek
Marciniak, Zuzanna
Nessler, Katarzyna
Wójtowicz, Ewa
Szozda, Nataliya
Kryj-Radziszewska, Elżbieta
Boroń, Maria
Gajos, Klaudia
Paziewski, Mateusz P.
Sajdak, Paweł
Windak, Adam
author_sort Oleszczyk, Marek
collection PubMed
description BACKGROUND: In manufacturers’ trials, vaccination against COVID-19 proved to be safe and effective. The officially reported frequency of vaccine adverse events (VAEs) in Poland is lower than that declared by the manufacturers. The anti-vaccination activists questioned the trustworthiness of official data. OBJECTIVES: The aim was to explore the real-life prevalence of VAEs in general practice settings and the factors that may influence it. METHODS: In this pragmatic, mixed prospective and retrospective study, patients vaccinated against COVID-19 between May and October 2021 in three GP practices in Krakow, Poland, were enrolled. Their demographic (age, sex, level of education) and clinical data (weight and height, smoking status, history of allergies, COVID-19 and chronic diseases) were collected. Then, they were interviewed about VAEs they experienced. RESULTS: Out of 1530 patients invited to participate, 1051 (69%) agreed and were eligible for analyses. Only 8.8% did not report any VAE. Pain at the injection site was the most frequently reported reaction (800, 76.2%). The most prevalent systemic ones were excessive fatigue/lethargy (527, 50.6%), sleep/circadian rhythm disturbances (433, 41.6%) and headache (399, 38.3%). Fifty required medical assistance − 39 experienced presyncope (3.7%) and 11 loss of consciousness (1.1%). Only two others were hospitalised. Females, younger adults, those with higher education and with a history of COVID-19 reported systemic VAEs more frequently, while those who were older and obese were less likely to report local reactions. CONCLUSION: Although more than 90% of patients vaccinated against COVID-19 in general practice settings may experience VAEs, in short-term observation, the vast majority are localised and mild.
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spelling pubmed-102494482023-06-09 COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland Oleszczyk, Marek Marciniak, Zuzanna Nessler, Katarzyna Wójtowicz, Ewa Szozda, Nataliya Kryj-Radziszewska, Elżbieta Boroń, Maria Gajos, Klaudia Paziewski, Mateusz P. Sajdak, Paweł Windak, Adam Eur J Gen Pract Original Articles BACKGROUND: In manufacturers’ trials, vaccination against COVID-19 proved to be safe and effective. The officially reported frequency of vaccine adverse events (VAEs) in Poland is lower than that declared by the manufacturers. The anti-vaccination activists questioned the trustworthiness of official data. OBJECTIVES: The aim was to explore the real-life prevalence of VAEs in general practice settings and the factors that may influence it. METHODS: In this pragmatic, mixed prospective and retrospective study, patients vaccinated against COVID-19 between May and October 2021 in three GP practices in Krakow, Poland, were enrolled. Their demographic (age, sex, level of education) and clinical data (weight and height, smoking status, history of allergies, COVID-19 and chronic diseases) were collected. Then, they were interviewed about VAEs they experienced. RESULTS: Out of 1530 patients invited to participate, 1051 (69%) agreed and were eligible for analyses. Only 8.8% did not report any VAE. Pain at the injection site was the most frequently reported reaction (800, 76.2%). The most prevalent systemic ones were excessive fatigue/lethargy (527, 50.6%), sleep/circadian rhythm disturbances (433, 41.6%) and headache (399, 38.3%). Fifty required medical assistance − 39 experienced presyncope (3.7%) and 11 loss of consciousness (1.1%). Only two others were hospitalised. Females, younger adults, those with higher education and with a history of COVID-19 reported systemic VAEs more frequently, while those who were older and obese were less likely to report local reactions. CONCLUSION: Although more than 90% of patients vaccinated against COVID-19 in general practice settings may experience VAEs, in short-term observation, the vast majority are localised and mild. Taylor & Francis 2022-12-05 /pmc/articles/PMC10249448/ /pubmed/36469611 http://dx.doi.org/10.1080/13814788.2022.2147500 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Oleszczyk, Marek
Marciniak, Zuzanna
Nessler, Katarzyna
Wójtowicz, Ewa
Szozda, Nataliya
Kryj-Radziszewska, Elżbieta
Boroń, Maria
Gajos, Klaudia
Paziewski, Mateusz P.
Sajdak, Paweł
Windak, Adam
COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland
title COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland
title_full COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland
title_fullStr COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland
title_full_unstemmed COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland
title_short COVID-19 vaccine short-term adverse events in the real-life family practice in Krakow, Poland
title_sort covid-19 vaccine short-term adverse events in the real-life family practice in krakow, poland
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249448/
https://www.ncbi.nlm.nih.gov/pubmed/36469611
http://dx.doi.org/10.1080/13814788.2022.2147500
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