Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation

OBJECTIVE: To investigate the effects of glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on endothelial dysfunction in LDL receptor-deficient (LDLR-KO) mice and ox-LDL-challenged human umbilical vein endothelial cells (HUVECs) and its possible mechanism. METHODS: LDLR-KO mice were rand...

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Detalles Bibliográficos
Autores principales: Ying, Wu, Meiyan, Song, Wen, Chen, Kaizu, Xu, Meifang, Wu, Liming, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249460/
https://www.ncbi.nlm.nih.gov/pubmed/37278349
http://dx.doi.org/10.1080/13510002.2023.2218684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249460/
https://www.ncbi.nlm.nih.gov/pubmed/37278349
http://dx.doi.org/10.1080/13510002.2023.2218684

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