Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice

Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined the effects of hepatocyte-specific (N-acetylgalactosamine-conjugated) antisense oligonucleotides targeting AGT (GalNAc AGT ASO) on AngII-mediated blood pressure (BP) regulation and atherosclerosis and...

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Detalles Bibliográficos
Autores principales: Ye, Dien, Wu, Congqing, Cai, Lei, Howatt, Deborah A., Liang, Ching-Ling, Katsumata, Yuriko, Mullick, Adam E., Temel, Ryan E., Danser, A.H. Jan, Daugherty, Alan, Lu, Hong S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249463/
https://www.ncbi.nlm.nih.gov/pubmed/37293374
http://dx.doi.org/10.36922/gtm.288

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