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Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults
BACKGROUND: Laboratory studies have linked nickel with the pathogenesis of cardiovascular disease (CVD); however, few observational studies in humans have confirmed this association. OBJECTIVE: This study aimed to use urinary nickel concentrations, as a biomarker of environmental nickel exposure, to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249564/ https://www.ncbi.nlm.nih.gov/pubmed/37360515 http://dx.doi.org/10.1007/s12403-023-00579-4 |
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author | Cheek, Joshua Fox, Sara Shuger Lehmler, Hans-Joachim Titcomb, Tyler J. |
author_facet | Cheek, Joshua Fox, Sara Shuger Lehmler, Hans-Joachim Titcomb, Tyler J. |
author_sort | Cheek, Joshua |
collection | PubMed |
description | BACKGROUND: Laboratory studies have linked nickel with the pathogenesis of cardiovascular disease (CVD); however, few observational studies in humans have confirmed this association. OBJECTIVE: This study aimed to use urinary nickel concentrations, as a biomarker of environmental nickel exposure, to evaluate the cross-sectional association between nickel exposure and CVD in a nationally representative sample of U.S. adults. METHODS: Data from a nationally representative sample (n = 2702) in the National Health and Nutrition Examination Survey 2017–20 were used. CVD (n = 326) was defined as self-reported physicians’ diagnoses of coronary heart disease, angina, heart attack, or stroke. Urinary nickel concentrations were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of CVD. RESULTS: Urinary nickel concentrations were higher in individuals with CVD (weighted median 1.34 μg/L) compared to those without CVD (1.08 μg/L). After adjustment for demographic, socioeconomic, lifestyle, and other risk factors for CVD, the ORs (95% CIs) for CVD compared with the lowest quartile of urinary nickel were 3.57 (1.73–7.36) for the second quartile, 3.61 (1.83–7.13) for the third quartile, and 2.40 (1.03–5.59) for the fourth quartile. Cubic spline regression revealed a non-monotonic, inverse U-shaped, association between urinary nickel and CVD (P(nonlinearity) < 0.001). CONCLUSIONS: Nickel exposure is associated with CVD in a non-monotonic manner among U.S. adults independent of well-known CVD risk factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12403-023-00579-4. |
format | Online Article Text |
id | pubmed-10249564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-102495642023-06-12 Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults Cheek, Joshua Fox, Sara Shuger Lehmler, Hans-Joachim Titcomb, Tyler J. Expo Health Original Paper BACKGROUND: Laboratory studies have linked nickel with the pathogenesis of cardiovascular disease (CVD); however, few observational studies in humans have confirmed this association. OBJECTIVE: This study aimed to use urinary nickel concentrations, as a biomarker of environmental nickel exposure, to evaluate the cross-sectional association between nickel exposure and CVD in a nationally representative sample of U.S. adults. METHODS: Data from a nationally representative sample (n = 2702) in the National Health and Nutrition Examination Survey 2017–20 were used. CVD (n = 326) was defined as self-reported physicians’ diagnoses of coronary heart disease, angina, heart attack, or stroke. Urinary nickel concentrations were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of CVD. RESULTS: Urinary nickel concentrations were higher in individuals with CVD (weighted median 1.34 μg/L) compared to those without CVD (1.08 μg/L). After adjustment for demographic, socioeconomic, lifestyle, and other risk factors for CVD, the ORs (95% CIs) for CVD compared with the lowest quartile of urinary nickel were 3.57 (1.73–7.36) for the second quartile, 3.61 (1.83–7.13) for the third quartile, and 2.40 (1.03–5.59) for the fourth quartile. Cubic spline regression revealed a non-monotonic, inverse U-shaped, association between urinary nickel and CVD (P(nonlinearity) < 0.001). CONCLUSIONS: Nickel exposure is associated with CVD in a non-monotonic manner among U.S. adults independent of well-known CVD risk factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12403-023-00579-4. Springer Netherlands 2023-06-08 /pmc/articles/PMC10249564/ /pubmed/37360515 http://dx.doi.org/10.1007/s12403-023-00579-4 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Paper Cheek, Joshua Fox, Sara Shuger Lehmler, Hans-Joachim Titcomb, Tyler J. Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults |
title | Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults |
title_full | Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults |
title_fullStr | Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults |
title_full_unstemmed | Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults |
title_short | Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults |
title_sort | environmental nickel exposure and cardiovascular disease in a nationally representative sample of u.s. adults |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249564/ https://www.ncbi.nlm.nih.gov/pubmed/37360515 http://dx.doi.org/10.1007/s12403-023-00579-4 |
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