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COVID-19 Infection and Outcomes in Newborn Screening Cohorts of Sickle Cell Trait and Sickle Cell Disease in Michigan and Georgia

The sickle cell mutation increases morbidity in those with sickle cell disease (SCD) and potentially sickle cell trait, impacting pulmonary, coagulation, renal, and other systems that are implicated in COVID-19 severity. There are no population-based registries for hemoglobinopathies, and they are n...

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Autores principales: Paulukonis, Susan T., Snyder, Angela, Smeltzer, Matthew P., Sutaria, Ankit N., Hurden, Isabel, Latta, Krista, Chennuri, Swathi, Vichinsky, Elliott, Reeves, Sarah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249598/
https://www.ncbi.nlm.nih.gov/pubmed/37083273
http://dx.doi.org/10.1097/MPH.0000000000002671
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author Paulukonis, Susan T.
Snyder, Angela
Smeltzer, Matthew P.
Sutaria, Ankit N.
Hurden, Isabel
Latta, Krista
Chennuri, Swathi
Vichinsky, Elliott
Reeves, Sarah L.
author_facet Paulukonis, Susan T.
Snyder, Angela
Smeltzer, Matthew P.
Sutaria, Ankit N.
Hurden, Isabel
Latta, Krista
Chennuri, Swathi
Vichinsky, Elliott
Reeves, Sarah L.
author_sort Paulukonis, Susan T.
collection PubMed
description The sickle cell mutation increases morbidity in those with sickle cell disease (SCD) and potentially sickle cell trait, impacting pulmonary, coagulation, renal, and other systems that are implicated in COVID-19 severity. There are no population-based registries for hemoglobinopathies, and they are not tracked in COVID-19 testing. We used COVID-19 test data from 2 states linked to newborn screening data to estimate COVID outcomes in people with SCD or trait compared with normal hemoglobin. We linked historical newborn screening data to COVID-19 tests, hospitalization, and mortality data and modeled the odds of hospitalization and mortality. Georgia’s cohort aged 0 to 12 years; Michigan’s, 0 to 33 years. Over 8% of those in Michigan were linked to positive COVID-19 results, and 4% in Georgia. Those with SCD showed significantly higher rates of COVID-19 hospitalization than the normal hemoglobin Black cohort, and Michigan had higher rates of mortality as well. Outcomes among those with the trait did not differ significantly from the normal hemoglobin Black group. People with SCD are at increased risk of COVID-19–related hospitalization and mortality and are encouraged to be vaccinated and avoid infection. Persons with the trait were not at higher risk of COVID-related severe outcomes.
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spelling pubmed-102495982023-06-09 COVID-19 Infection and Outcomes in Newborn Screening Cohorts of Sickle Cell Trait and Sickle Cell Disease in Michigan and Georgia Paulukonis, Susan T. Snyder, Angela Smeltzer, Matthew P. Sutaria, Ankit N. Hurden, Isabel Latta, Krista Chennuri, Swathi Vichinsky, Elliott Reeves, Sarah L. J Pediatr Hematol Oncol Medical Progress The sickle cell mutation increases morbidity in those with sickle cell disease (SCD) and potentially sickle cell trait, impacting pulmonary, coagulation, renal, and other systems that are implicated in COVID-19 severity. There are no population-based registries for hemoglobinopathies, and they are not tracked in COVID-19 testing. We used COVID-19 test data from 2 states linked to newborn screening data to estimate COVID outcomes in people with SCD or trait compared with normal hemoglobin. We linked historical newborn screening data to COVID-19 tests, hospitalization, and mortality data and modeled the odds of hospitalization and mortality. Georgia’s cohort aged 0 to 12 years; Michigan’s, 0 to 33 years. Over 8% of those in Michigan were linked to positive COVID-19 results, and 4% in Georgia. Those with SCD showed significantly higher rates of COVID-19 hospitalization than the normal hemoglobin Black cohort, and Michigan had higher rates of mortality as well. Outcomes among those with the trait did not differ significantly from the normal hemoglobin Black group. People with SCD are at increased risk of COVID-19–related hospitalization and mortality and are encouraged to be vaccinated and avoid infection. Persons with the trait were not at higher risk of COVID-related severe outcomes. Lippincott Williams & Wilkins 2023-05 2023-03-20 /pmc/articles/PMC10249598/ /pubmed/37083273 http://dx.doi.org/10.1097/MPH.0000000000002671 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Medical Progress
Paulukonis, Susan T.
Snyder, Angela
Smeltzer, Matthew P.
Sutaria, Ankit N.
Hurden, Isabel
Latta, Krista
Chennuri, Swathi
Vichinsky, Elliott
Reeves, Sarah L.
COVID-19 Infection and Outcomes in Newborn Screening Cohorts of Sickle Cell Trait and Sickle Cell Disease in Michigan and Georgia
title COVID-19 Infection and Outcomes in Newborn Screening Cohorts of Sickle Cell Trait and Sickle Cell Disease in Michigan and Georgia
title_full COVID-19 Infection and Outcomes in Newborn Screening Cohorts of Sickle Cell Trait and Sickle Cell Disease in Michigan and Georgia
title_fullStr COVID-19 Infection and Outcomes in Newborn Screening Cohorts of Sickle Cell Trait and Sickle Cell Disease in Michigan and Georgia
title_full_unstemmed COVID-19 Infection and Outcomes in Newborn Screening Cohorts of Sickle Cell Trait and Sickle Cell Disease in Michigan and Georgia
title_short COVID-19 Infection and Outcomes in Newborn Screening Cohorts of Sickle Cell Trait and Sickle Cell Disease in Michigan and Georgia
title_sort covid-19 infection and outcomes in newborn screening cohorts of sickle cell trait and sickle cell disease in michigan and georgia
topic Medical Progress
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249598/
https://www.ncbi.nlm.nih.gov/pubmed/37083273
http://dx.doi.org/10.1097/MPH.0000000000002671
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