Biotransformation novel advances – 2021 year in review*

Biotransformation field is constantly evolving with new molecular structures and discoveries of metabolic pathways that impact efficacy and safety. Recent review by Kramlinger et al. (2022) nicely captures the future (and the past) of highly impactful science of biotransformation (see the first arti...

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Detalles Bibliográficos
Autores principales: Khojasteh, S. Cyrus, Argikar, Upendra A., Cho, Sungjoon, Crouch, Rachel, Heck, Carley J. S., Johnson, Kevin M., Kalgutkar, Amit S., King, Lloyd, Maw, Hlaing (Holly), Seneviratne, Herana Kamal, Wang, Shuai, Wei, Cong, Zhang, Donglu, Jackson, Klarissa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249656/
https://www.ncbi.nlm.nih.gov/pubmed/35815654
http://dx.doi.org/10.1080/03602532.2022.2097253
Descripción
Sumario:Biotransformation field is constantly evolving with new molecular structures and discoveries of metabolic pathways that impact efficacy and safety. Recent review by Kramlinger et al. (2022) nicely captures the future (and the past) of highly impactful science of biotransformation (see the first article). Based on the selected articles, this review was categorized into three sections: (1) new modalities biotransformation, (2) drug discovery biotransformation, and (3) drug development biotransformation (Table 1).

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