Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

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Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CL(pro)) encoded by diverse coronaviruses, including Severe Acute Respiratory...

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Detalles Bibliográficos
Autores principales: Tsu, Brian V., Agarwal, Rimjhim, Gokhale, Nandan S., Kulsuptrakul, Jessie, Ryan, Andrew P., Fay, Elizabeth J., Castro, Lennice K., Beierschmitt, Christopher, Yap, Christina, Turcotte, Elizabeth A., Delgado-Rodriguez, Sofia E., Vance, Russell E., Hyde, Jennifer L., Savan, Ram, Mitchell, Patrick S., Daugherty, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249858/
https://www.ncbi.nlm.nih.gov/pubmed/37289745
http://dx.doi.org/10.1371/journal.pbio.3002144
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