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Nano-DMS-MaP allows isoform-specific RNA structure determination

Genome-wide measurements of RNA structure can be obtained using reagents that react with unpaired bases, leading to adducts that can be identified by mutational profiling on next-generation sequencing machines. One drawback of these experiments is that short sequencing reads can rarely be mapped to...

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Detalles Bibliográficos
Autores principales: Bohn, Patrick, Gribling-Burrer, Anne-Sophie, Ambi, Uddhav B., Smyth, Redmond P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250195/
https://www.ncbi.nlm.nih.gov/pubmed/37106231
http://dx.doi.org/10.1038/s41592-023-01862-7