Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo signal-to-noise ratios, saturating activation kinetics and exclusion from postsynaptic densities. Using a multiassay scree...

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Detalles Bibliográficos
Autores principales: Aggarwal, Abhi, Liu, Rui, Chen, Yang, Ralowicz, Amelia J., Bergerson, Samuel J., Tomaska, Filip, Mohar, Boaz, Hanson, Timothy L., Hasseman, Jeremy P., Reep, Daniel, Tsegaye, Getahun, Yao, Pantong, Ji, Xiang, Kloos, Marinus, Walpita, Deepika, Patel, Ronak, Mohr, Manuel A., Tillberg, Paul W., Looger, Loren L., Marvin, Jonathan S., Hoppa, Michael B., Konnerth, Arthur, Kleinfeld, David, Schreiter, Eric R., Podgorski, Kaspar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250197/
https://www.ncbi.nlm.nih.gov/pubmed/37142767
http://dx.doi.org/10.1038/s41592-023-01863-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250197/
https://www.ncbi.nlm.nih.gov/pubmed/37142767
http://dx.doi.org/10.1038/s41592-023-01863-6

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