Cargando…

AFM-based force spectroscopy unravels stepwise formation of the DNA transposition complex in the widespread Tn3 family mobile genetic elements

Transposon Tn4430 belongs to a widespread family of bacterial transposons, the Tn3 family, which plays a prevalent role in the dissemination of antibiotic resistance among pathogens. Despite recent data on the structural architecture of the transposition complex, the molecular mechanisms underlying...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernandez, Maricruz, Shkumatov, Alexander V, Liu, Yun, Stulemeijer, Claire, Derclaye, Sylvie, Efremov, Rouslan G, Hallet, Bernard, Alsteens, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250215/ https://www.ncbi.nlm.nih.gov/pubmed/37026471 http://dx.doi.org/10.1093/nar/gkad241

Ejemplares similares

Structural insight into Tn3 family transposition mechanism
por: Shkumatov, Alexander V., et al.
Publicado: (2022)

Conformational toggling controls target site choice for the heteromeric transposase element Tn7
por: Shi, Qiaojuan, et al.
Publicado: (2015)

A highly divergent archaeo-eukaryotic primase from the Thermococcus nautilus plasmid, pTN2
por: Gill, Sukhvinder, et al.
Publicado: (2014)

The somatic piRNA pathway controls germline transposition over generations
por: Barckmann, Bridlin, et al.
Publicado: (2018)

Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation
por: Meek, Katheryn
Publicado: (2020)

Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality
por: Grieb, Maj Svea, et al.
Publicado: (2017)

Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine
por: Allgayer, Julia, et al.
Publicado: (2016)

Mapping the driving forces of chromosome structure and segregation in Escherichia coli
por: Kuwada, Nathan J., et al.
Publicado: (2013)

Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis
por: Le, Shimin, et al.
Publicado: (2014)

Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells
por: Maestroni, Laetitia, et al.
Publicado: (2020)

Force and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein
por: Fu, Hongxia, et al.
Publicado: (2013)

Estimation of the RNU2 macrosatellite mutation rate by BRCA1 mutation tracing
por: Tessereau, Chloé, et al.
Publicado: (2014)

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity
por: Liptak, Cary, et al.
Publicado: (2018)

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ
por: Schellenbauer, Amelie, et al.
Publicado: (2021)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

Viral AlkB proteins repair RNA damage by oxidative demethylation
por: van den Born, Erwin, et al.
Publicado: (2008)

DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts
por: Labit, Hélène, et al.
Publicado: (2008)

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation
por: Williamson, Elizabeth A., et al.
Publicado: (2008)

Editing of misaligned 3′-termini by an intrinsic 3′–5′ exonuclease activity residing in the PHP domain of a family X DNA polymerase
por: Baños, Benito, et al.
Publicado: (2008)

Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots
por: Liapis, Evagelos, et al.
Publicado: (2008)

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
por: Jayaram, Sumithra, et al.
Publicado: (2008)

The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase δ
por: Selak, Nives, et al.
Publicado: (2008)

Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants
por: Restle, Anja, et al.
Publicado: (2008)

Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting
por: Iiizumi, Susumu, et al.
Publicado: (2008)

Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences
por: Kappeler, Michael, et al.
Publicado: (2008)

REV1 restrains DNA polymerase ζ to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo
por: Szüts, Dávid, et al.
Publicado: (2008)

Identification of the Xenopus DNA2 protein as a major nuclease for the 5′→3′ strand-specific processing of DNA ends
por: Liao, Shuren, et al.
Publicado: (2008)

Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
por: He, Wei, et al.
Publicado: (2008)

Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2
por: Malik, Punjab S., et al.
Publicado: (2008)

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
por: Mortusewicz, Oliver, et al.
Publicado: (2011)

Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA
por: Gueranger, Quentin, et al.
Publicado: (2011)

Use of RecA fusion proteins to induce genomic modifications in zebrafish
por: Liao, Hsin-Kai, et al.
Publicado: (2011)

Escherichia coli YafP protein modulates DNA damaging property of the nitroaromatic compounds
por: Gutierrez, Arnaud, et al.
Publicado: (2011)

Two forms of ribosomal protein L2 of Escherichia coli that inhibit DnaA in DNA replication
por: Chodavarapu, Sundari, et al.
Publicado: (2011)

A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage
por: He, Wei, et al.
Publicado: (2011)

A cytoplasm-specific activity encoded by the Trithorax-like ATX1 gene
por: Ndamukong, Ivan, et al.
Publicado: (2011)

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
por: Kumar, Dinesh, et al.
Publicado: (2010)

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase
por: Nora, Gerald J., et al.
Publicado: (2010)

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
por: Mansour, Wael Y., et al.
Publicado: (2010)

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 ‘gate’
por: Bochman, Matthew L., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_c9irn38centeioreqh8sn0n2sq