Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA sampling and recruitment to oxidized bases in living cells

The DNA-glycosylase OGG1 oversees the detection and clearance of the 7,8-dihydro-8-oxoguanine (8-oxoG), which is the most frequent form of oxidized base in the genome. This lesion is deeply buried within the double-helix and its detection requires careful inspection of the bases by OGG1 via a mechan...

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Detalles Bibliográficos
Autores principales: D’Augustin, Ostiane, Gaudon, Virginie, Siberchicot, Capucine, Smith, Rebecca, Chapuis, Catherine, Depagne, Jordane, Veaute, Xavier, Busso, Didier, Di Guilmi, Anne-Marie, Castaing, Bertrand, Radicella, J Pablo, Campalans, Anna, Huet, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250219/
https://www.ncbi.nlm.nih.gov/pubmed/37021552
http://dx.doi.org/10.1093/nar/gkad243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250219/
https://www.ncbi.nlm.nih.gov/pubmed/37021552
http://dx.doi.org/10.1093/nar/gkad243

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