Cargando…
Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering
Tyrosine-type site-specific recombinases (Y-SSRs) are versatile tools for genome engineering due to their ability to mediate excision, integration, inversion and exchange of genomic DNA with single nucleotide precision. The ever-increasing need for sophisticated genome engineering is driving efforts...
Autores principales: | Jelicic, Milica, Schmitt, Lukas Theo, Paszkowski-Rogacz, Maciej, Walder, Angelika, Schubert, Nadja, Hoersten, Jenna, Sürün, Duran, Buchholz, Frank |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250229/ https://www.ncbi.nlm.nih.gov/pubmed/37158248 http://dx.doi.org/10.1093/nar/gkad366 |
Ejemplares similares
-
Pairing of single mutations yields obligate Cre-type site-specific recombinases
por: Hoersten, Jenna, et al.
Publicado: (2021) -
A heterodimer of evolved designer-recombinases precisely excises a human genomic DNA locus
por: Lansing, Felix, et al.
Publicado: (2020) -
Redesign of the monomer–monomer interface of Cre recombinase yields an obligate heterotetrameric complex
por: Zhang, Chi, et al.
Publicado: (2015) -
Prediction of designer-recombinases for DNA editing with generative deep learning
por: Schmitt, Lukas Theo, et al.
Publicado: (2022) -
Correction of a Factor VIII genomic inversion with designer-recombinases
por: Lansing, Felix, et al.
Publicado: (2022)